中国现代医学杂志2017，Vol.27Issue(5)：33-37,5.DOI:10.3969/j.issn.1005-8982.2017.05.007
三阴性乳腺癌患者表皮生长因子受体-3的表达与肝转移的相关性及意义
Significance of HER-3 in predicting liver metastasis in three negative breast cancer patient
黄少江1
作者信息
- 1. 第三军医大学新桥医院 肿瘤科,重庆 400037
- 折叠
摘要
Abstract
Objective To investigate the expression of HER-3 in TNBC tissues, and to explore the rela tionship and clinical value with liver metastasis. Methods TNBC tissue specimens and clinical data were collected, and the expression of HER-3 was detected by immunohistochemical and Western blot method. Clin-icopathological features and correlation with liver metastasis were analyzed, and the prognosis was analyzed by Kaplan Meier survival analysis. Results The positive rate of HER-3 in TNBC was 72.63% (69/95), and had correlation with TNM stage and lymph node status but not related to nuclear grade, p53 or tumor size. The incidence of liver metastasis in HER-3 positive group was significantly higher than the negative group sta-tistically. The median DFS of HER-3 negative and positive group were 18.4 and 14.5 months, and the median OS was 31.2 and 26.3 months with statistically significant. Conclusions The HER-3 expresses in TNBC, and promotes the invasion of cancer cells, and is closely related to liver metastasis, and can be used as a potential biomarker for assessing the prognosis of TNBC.关键词
表皮生长因子受体-3/三阴乳腺癌/肝转移Key words
HER-3/triple-negative breast cancer/liver metastasis分类
医药卫生引用本文复制引用
黄少江..三阴性乳腺癌患者表皮生长因子受体-3的表达与肝转移的相关性及意义[J].中国现代医学杂志,2017,27(5):33-37,5.
