中国现代医学杂志2017，Vol.27Issue(6)：50-53,4.DOI:10.3969/j.issn.1005-8982.2017.06.010
果蝇EZH2与乳腺癌分子分型及临床病理特征的关系
Correlations of enhancer of Drosophila zeste homolog 2 with molecular subtypes and clinicopathological parameters of breast cancer
摘要
Abstract
Objective To investigate the correlations of enhancer of Drosophila zeste homolog 2 (EZH2) with molecular subtypes and clinicopathological parameters of breast cancer. Methods The breast cancers were classified into several molecular subtypes, according to the new standard of molecular classification of breast cancer. The expression of EZH2 in paraffin sections of breast cancer tissues was tested through immunohistochemistry method. The correlations of EZH2 with clinicopathological parameters and new molecular subtypes of breast cancers were analyzed and compared through Chi-square test. The correlation between EZH2 and disease-free survival of the breast cancer patients was analyzed through Kaplan-Meier method. Results In the 13 cases of Luminal A subtype, 3 cases had high EZH2 expression (23.08%). In the 10 cases of Luminal B subtype, 5 cases had high EZH2 expression (50.00%). In the 7 cases of Her-2 over-expression subtype, there were 3 cases of high EZH2 expression (42.86%). In the 12 cases of triple-negative breast cancer subtype, there were 10 cases of high EZH2 expression (83.33%). Significant differences existed in the expression of EZH2 among the four groups of molecular subtypes of breast cancer (P< 0.05). There was significant difference in the disease-free survival between the breast cancer patients with high EZH2 expression and those with low EZH2 expression (P<0.05). Conclusions EZH2 might be one of the indexes to predict the prognosis of breast cancer.关键词
果蝇Zeste基因增强子人类同源物2/乳腺癌/分子分型/免疫组织化学Key words
enhancer of Drosophila zeste homolog 2/breast cancer/molecular subtype/immunohisto-chemistry分类
医药卫生引用本文复制引用
李杰宝,喻晓程,田野..果蝇EZH2与乳腺癌分子分型及临床病理特征的关系[J].中国现代医学杂志,2017,27(6):50-53,4.基金项目
湖北省2015年武汉市卫计委临床医学课题(No:WX15B17) （No:WX15B17）
