中国现代医学杂志2017，Vol.27Issue(6)：88-92,5.DOI:10.3969/j.issn.1005-8982.2017.06.018
益气复脉对中晚期肺癌患者免疫功能和生存质量的影响
Effects of Yiqifumai injection on immune function and quality of life in patients with advanced lung cancer
摘要
Abstract
Objective To investigate the effect of Yiqifumai injection (freeze-drying) on the immunity and quality of life in patients with advanced lung cancer. Methods In this study, 63 patients with advanced lung cancer who were diagnosed by pathology and cytology and accepted chemotherapy in our hospital from September 2013 to August 2014 were taken as control group, and 67 cases of the same kind of patients from January 2015 to December 2015 were selected as observation group. The patients in the two groups were giv-en the same chemotherapy regimen and auxiliary health guidance, nutritional support, psychological and reha-bilitation exercise guidance, as well as analgesics and antiemetics. The observation group had additional treat-ment of Yiqifumai injection. After 6 courses hematologic parameters of immune function, quality of life, Karnofsky score, curative effect and adverse reactions were compared between the two groups. Results In the observation group the amount of C-reactive protein and white blood cells was reduced (P<0.05), the activity of NKT cells was increased, the proportions of CD3+ and CD4+T cell subsets and CD4/CD8+ ratio were in-creased (P< 0.05). The immune function of the body was enhanced. The scores of quality of life of the pa-tients in the two groups had no significant difference before treatment, but increased in both groups after treatment. The improvement in the cognitive function and economic difficulties was consistent in the two group, but that in the remaining dimensions was better in the observation group (P<0.05). After treatment, the Karnofsky score of the observation group was significantly different from that of the control group (P<0.05). The total effective rate was 95.52% in the observation group and 60.32% in the control group, and there was significant difference between the two groups (P<0.05). In the observation group, white blood cell and platelet count and hemoglobin level decreased, abnormal liver and renal function was observed, and the differences between the two groups had statistical significance (P<0.05). Conclusions Application of Yiqifumai injection can not only improve the patients' immune function, but also reduce the occurrence of adverse reactions and improve the quality of life of the patients.关键词
注射用益气复脉/肺癌/免疫功能/生存质量Key words
Yiqifumai injection/lung cancer/immune function/quality of life分类
医药卫生引用本文复制引用
郭占芳,张红武,杨如意,孙兆,刘永萍..益气复脉对中晚期肺癌患者免疫功能和生存质量的影响[J].中国现代医学杂志,2017,27(6):88-92,5.基金项目
青海大学附属医院中青年科研基金(No:ASRF-2014-03) （No:ASRF-2014-03）
