中国药科大学学报2017，Vol.48Issue(1)：110-116,7.DOI:10.11665/j.issn.1000-5048.20170117
Ras/Raf/MEK/ERK信号通路参与自噬调控作用的研究进展
Advances in research on the modulation of autophagy by Ras/Raf/MEK/ERK signaling pathway
摘要
Abstract
Autophagy is a conserved self-defense mechanism of organism, degrading the necrotic organelles and excess protein into small molecules for recycling. Autophagy plays a role in both physiological and pathological condition, influencing the expression of intracellular substance through multiple signaling pathways. Although it has been demonstrated that Ras/Raf/MEK/ERK signaling pathway was not only extensively involved in the regu-lation of cell growth, proliferation, differentiation and apoptosis, but was also implicated in autophagy and autoph-agic cell death, though its detailed mechanisms involved in regulation of autophagy has not been fully elucidated yet. This review focused on the advances of autophagy induced by Ras/Raf/MEK/ERK signaling pathway, to bet-ter understand the role of Ras/Raf/MEK/ERK signaling pathway in regulation of autophagy.关键词
Ras/Raf/MEK/ERK信号通路/自噬/B-Raf/K-Ras/抗肿瘤Key words
Ras/Raf/MEK/ERK pathway/autophagy/B-Raf/K-Ras/anti-tumor分类
医药卫生引用本文复制引用
王雪,张评浒..Ras/Raf/MEK/ERK信号通路参与自噬调控作用的研究进展[J].中国药科大学学报,2017,48(1):110-116,7.基金项目
新世纪优秀人才计划资助项目(No． NCET-12-0975) （No． NCET-12-0975）
教育部回国留学人才启动项目资助项目 （）
江苏省新药筛选重点实验室自主探索项目资助项目(No． JKLDS2015ZZ-8)The study is supported by the New Century Excellent Researcher Award Program ( No． NCET-12-0975) （No． JKLDS2015ZZ-8）
the Returned Overseas Researcher Startup Program from Ministry of Education （）
and the Self-Exploration Project from Jiangsu Key Lab for New Drug Screen-ing( No． JKLDS2015ZZ-8) （ No． JKLDS2015ZZ-8）
