中国药房2017，Vol.28Issue(5)：607-610,4.DOI:10.6039/j.issn.1001-0408.2017.05.08
我院铜绿假单胞菌耐药性与抗菌药物使用强度相关性分析
Analysis of the Correlation between Drug Resistance of Pseudomonas aeruginosa and Antibiotics Use Den-sity in Our Hospital
摘要
Abstract
OBJECTIVE:To provide reference for rational use of antibiotics to treat Pseudomonas aeruginosa (PA) infection in the clinic. METHODS:Resistant rate of PA in our hospital during 2011-2015 were analyzed retrospectively. Antibiotics use densi-ty(AUD)of 10 commonly used antibiotics were analyzed statistically,and the correlation of resistant rate with AUD was investi-gated by Spearman correlation analysis. RESULTS:One thousaud and eleven strains of PA were isolated in our hospital during 2011-2014,detection rate of PA always occupied the top 5 place. Top 3 antibiotics in the list of AUD were levofloxacin,ceftazi-dime,cefoperazone sodium and tazobactam sodium. AUD of piperacillin sodium and tazobactam sodium,levofloxacin,ciprofloxa-cin and meropenem were positively correlated with resistant rate of PA(r were 1.000,0.900,1.000,1.000,P<0.05). AUD of ce-foperazone sodium and tazobactam sodium were negatively correlated with resistant rate of PA(r=-0.900,P<0.05). AUD of imi-penem and cilastatin sodium,ceftazidime,gentamicin,aztreonam and amikacin had no correlation with resistant rate of PA(P>0.05). CONCLUSIONS:There is correlation between AUD of antibiotics and resistant rate of PA. It is of important significance to detect resistant rate of PA and the use of antibiotics regularly. Antibiotics should be selected cautiously in accordance with bacterial monitoring data,results of drug sensitivity tests,the amount and resistant rate of antibiotics,etc,in order to reduce resistant PA.关键词
铜绿假单胞菌/耐药性/抗菌药物/使用强度/相关性Key words
Pseudomonas aeruginosa/Drug resistance/Antibiotics/Antibiotics use density/Correlation分类
医药卫生引用本文复制引用
付滢舟,杨立平,谌赟,龚倩,谷秀梅,朱青,符一岚,曹丽芝..我院铜绿假单胞菌耐药性与抗菌药物使用强度相关性分析[J].中国药房,2017,28(5):607-610,4.基金项目
湖南省自然科学基金资助项目 （）
