中国药房2017，Vol.28Issue(7)：893-895,3.DOI:10.6039/j.issn.1001-0408.2017.07.08
红栀骨通凝胶膏对家兔皮肤刺激性的研究
Study on the Skin Irritation of Hongzhi Gutong Cataplasm in Rabbits
摘要
Abstract
OBJECTIVE:To study the safety of percutaneous administration of Hongzhi gutong cataplasm. METHODS:Rab-bits were taken for single dose in complete skin irritation test(n=4),single dose in damaged skin irritation test(n=4)and multi-ple doses in complete skin irritation test(n=4). The left and right sides of the skin respectively paste 3 cm×3 cm blank matrix and Hongzhi gutong cataplasm for 24 h(calculated by crude drug of 0.14 g). After removing tape 1,24,48,72 h,the erythema and edema in hair removal site of rabbits in the former 2 tests were observed;after 24 h of administration,the rabbits in the last group were administrated again after exposing the administration area for 1 h,repeated 3 times,the erythema and edema in hair removal site after removing tape the first,second time and 1,24,48,72 h in the third time were respectively observed. RESULTS:In the 3 experiments,the scores of erythema and edema of all rabbits were 0,and skin irritation was evaluated as no irritation. CONCLU-SIONS:Hongzhi gutong cataplasm has no skin irritation in rabbits.关键词
红栀骨通凝胶膏/皮肤刺激性/完整皮肤/破损皮肤/单次给药/多次给药/家兔Key words
Hongzhi gutong cataplasm/Skin irritation/Complete skin/Damaged skin/Single dose/Multiple doses/Rabbits分类
医药卫生引用本文复制引用
彭伟文,王珠强,吴飞..红栀骨通凝胶膏对家兔皮肤刺激性的研究[J].中国药房,2017,28(7):893-895,3.基金项目
广东省中医药强省立项资助科研课题(No. 20141284) （No. 20141284）
