中国药房2017，Vol.28Issue(7)：906-909,4.DOI:10.6039/j.issn.1001-0408.2017.07.12
广西倒地铃体外抗氧化活性的谱效关系研究
Study on the Spectrum-effect Relationship of Antioxidant Activity in vitro of Cardiospermum halicacabum from Guangxi
摘要
Abstract
OBJECTIVE:To establish the fingerprints of 11 batches of Cardiospermum halicacabum from Guangxi,and detect its spectrum-effect relationship of antioxidant activity in vitro,and provide reference for revealing the material basis for its antioxi-dant activity. METHODS:HPLC was conducted to establish the fingerprints of 11 batches of C. halicacabum from Guangxi,the 1, 1-diphenyl-2-trinitrobenzene hydrazine(DPPH)free radical scavenging method was used to determine the antioxidant activity in vi-tro of C. halicacabum from different origins,and bivariate correlation analysis was adopted to detect the spectrum-effect relation-ship of antioxidant activity in vitro. RESULTS:The similarities of 11 batches of C. halicacabum from Guangxi were all more than 0.9,and the content change of peak 2(protocatechuic acid),3,4,12 in 16 common peaks was closely related to the DPPH free radical scavenging activity. CONCLUSIONS:The chemical composition of C. halicacabum from different origins in Guangxi is ba-sically consistent,while there are some differences in the quality of the producing area. The protocatechuic acid (peak 2) and the unknown compounds represented by peak 3,4,12 may be the pharmacodynamic material basis of its antioxidant activity.关键词
广西/倒地铃/体外抗氧化活性/指纹图谱Key words
Guangxi/Cardiospermum halicacabum/Antioxidant activity in vitro/Fingerprint分类
医药卫生引用本文复制引用
陈君,陈丽,韦建华..广西倒地铃体外抗氧化活性的谱效关系研究[J].中国药房,2017,28(7):906-909,4.基金项目
广西高校科学技术研究项目(No.2013YB287) （No.2013YB287）
