中国药房2017，Vol.28Issue(7)：961-963,3.DOI:10.6039/j.issn.1001-0408.2017.07.28
正交试验优化复方粉背雷公藤凝胶剂处方
Formulation Optimization of Compound Tripterygium Hypoglaucum Gel by Orthogonal Test
摘要
Abstract
OBJECTIVE:To optimize the formulation of Compound tripterygium hypoglaucum gel. METHODS:Using the comprehensive score(total score was 15.0)composed by forming property,glossiness,uniformity,viscosity,pH,spreadable prop-erty and stability as indexes,using the usage amount of carbomer 940,propylene glycol,triethanolamine and extracts in formula as study factors,orthogonal test was designed to optimized the formulation of Compound tripterygium hypoglaucum gel,and the verification test was conducted. RESULTS:The optimal matrix formulation was as follow as carbomer 9401.0 g,azone 2.0 g,so-dium bisulfite 0.4 g,extracts 50 mL,propylene glycol 10 g,triethanolamine 1.0 g,adding water to 100 g. The average comprehen-sive score of the gel in verification test was 14.8 (RSD=1.35%,n=3). CONCLUSIONS:The optimized formulation of Com-pound tripterygium hypoglaucum gel shows good forming property,the quality meets the requirements.关键词
复方粉背雷公藤凝胶剂/正交试验/处方优化/成型性Key words
Compound tripterygium hypoglaucum gel/Orthogonal test/Formulation optimization/Forming property分类
医药卫生引用本文复制引用
杨媛媛,姜旭,王宇卿..正交试验优化复方粉背雷公藤凝胶剂处方[J].中国药房,2017,28(7):961-963,3.基金项目
河南省中医药科学研究专项课题(No.2014ZY02019) （No.2014ZY02019）
