中国药房2017，Vol.28Issue(7)：967-970,4.DOI:10.6039/j.issn.1001-0408.2017.07.30
阿苯达唑纳米脂质体冻干粉的制备及性质考察
Preparation and Properties Study of Albendazole Nanoliposomes Freeze-dried Powder
摘要
Abstract
OBJECTIVE:To prepare the Albendazole nanoliposomes freeze-dried power and study its properties. METHODS:Freeze-drying method was conducted to prepare Albendazole nanoliposomes freeze-dried power,using the particle size,encapsula-tion efficiency,appearance,redispersibility as indexes,single factor test was combined with orthogonal test to screen freeze-drying preparation technology. The morphological changes,particle size,Zeta potential,moisture content,12 months stability at 4 ℃ be-fore and after freeze-drying were detected. RESULTS:Plus a total content of freeze-dried protective agent was 10%,the ratio of glucose-trehalose-mannitol was 1.0:1.0:3.0,using quick-freeze,pre-freezing 18 h in -35 ℃ refrigerator,dry-freezing 48 h to ob-tain freeze-dried powder. Compared with before freeze-drying,the freeze-dried liposomal morphology had no obvious changes, showing clear phospholipid bilayer membrane structure;the particle sizes before and after freeze-drying were (208.63 ± 1.04) nm and (223.04 ± 2.02) nm,Zeta potentials were (-15.6 ± 0.04) mV and (-19.4 ± 0.06) mV,encapsulation efficiencies were (94.62±0.49)%and(91.10±0.46)%(n=3),respectively. Compared with liposomes,liposomes freeze-dried power had good sta-bility in 12 months at 4 ℃. CONCLUSIONS:Albendazole nanoliposomes freeze-dried power is prepared successfully,its stability is superior to albendazole nanoliposomes,and the freeze-drying technology is feasible.关键词
阿苯达唑/纳米脂质体/冻干粉/粒径/包封率/稳定性/正交试验Key words
Albendazole/Nanoliposomes/Freeze-dried powder/Particle size/Encapsulation efficiency/Stability/Orthogonal test分类
医药卫生引用本文复制引用
陈蓓,陈春燕,高惠静,王建华,赵军..阿苯达唑纳米脂质体冻干粉的制备及性质考察[J].中国药房,2017,28(7):967-970,4.基金项目
新疆重大疾病医学重点实验室——省部共建国家重点实验室培育基地开放项目(No.SKLIB-XJMDR-2014-10) （No.SKLIB-XJMDR-2014-10）
