阿苯达唑纳米脂质体冻干粉的制备及性质考察OA北大核心CSTPCD
Preparation and Properties Study of Albendazole Nanoliposomes Freeze-dried Powder
目的:制备阿苯达唑纳米脂质体冻干粉并对其性质进行考察.方法:利用冷冻干燥法制备阿苯达唑纳米脂质体冻干粉,以粒径、包封率联合外观、再分散性为指标,采用单因素试验联合正交试验筛选冻干处方工艺.考察冻干前、后脂质体的形态学变化、粒径、Zeta电位、水分含量、4℃下12个月的稳定性.结果:采用外加冻干保护剂的总量为10%,其中葡萄糖-海藻糖-甘露醇配比为1.0:1.0:3.0,以速冻的方式,于-35℃冰箱预冻18 h,冷冻干燥48 h获得冻干粉.与冻干前…查看全部>>
OBJECTIVE:To prepare the Albendazole nanoliposomes freeze-dried power and study its properties. METHODS:Freeze-drying method was conducted to prepare Albendazole nanoliposomes freeze-dried power,using the particle size,encapsula-tion efficiency,appearance,redispersibility as indexes,single factor test was combined with orthogonal test to screen freeze-drying preparation technology. The morphological changes,particle size,Zeta potential,moisture content,12 mo…查看全部>>
陈蓓;陈春燕;高惠静;王建华;赵军
新疆医科大学第一附属医院药学部,乌鲁木齐 830011新疆医科大学第一附属医院药学部,乌鲁木齐 830011新疆医科大学第一附属医院药学部,乌鲁木齐 830011新疆医科大学第一附属医院药学部,乌鲁木齐 830011新疆医科大学第一附属医院药学部,乌鲁木齐 830011
医药卫生
阿苯达唑纳米脂质体冻干粉粒径包封率稳定性正交试验
AlbendazoleNanoliposomesFreeze-dried powderParticle sizeEncapsulation efficiencyStabilityOrthogonal test
《中国药房》 2017 (7)
967-970,4
新疆重大疾病医学重点实验室——省部共建国家重点实验室培育基地开放项目(No.SKLIB-XJMDR-2014-10)
评论