中国药房2017，Vol.28Issue(8)：1041-1044,4.DOI:10.6039/j.issn.1001-0408.2017.08.09
注射用乌司他丁与2种常用溶剂在输液泵中的配伍稳定性考察
Study on Compatibility Stability of Ulinastatin for Injection with 2 Commonly Used Solvents in the Infusion Pump
摘要
Abstract
OBJECTIVE:To investigate the compatibility stability of Ulinastatin for injection with 2 commonly used solvents in the infusion pump.METHODS:After Ulinastatin for injection 500 000 U was respectively added into 0.9％ Sodium chloride injection and 5％ Glucose injection 50 mL,the appearance of the mixture at 25 ℃,37 ℃ were observed at 0,1,2,4,8,12,24 h,re spctively,pH value and the number of insoluble particles were measured.The relative percentage of ulinastatin in the mixture was determined by HPGFC.RESULTS:Under this condition,the appearance and pH value of the mixture had no significant change within 24 h;the number of particles ≥10 μm was lower than 25 particle/mL,and that ≥25 μm was lower than 3 particle/mL,which was in line with the pharmacopeia standard.The relative percentage of ulinastatin within 24 h ranged 99.45％-102.55％.CONCLUSIONS:After mixed with 0.9％ Sodium chloride injection and 5％ Glucose injection,Ulinastatin for injection keep stable within 24 h at 25 ℃,37 ℃ and can be used for continuous administration in the infusion pump.关键词
乌司他丁/高效液相凝胶过滤色谱法/含量/配伍/稳定性/输液泵Key words
Ulinastatin/HPGFC/Content/Compatibility/Stability/Infusion pump分类
医药卫生引用本文复制引用
林淑瑜,甘惠贞,李玉堂,潘丹婷,陈志民..注射用乌司他丁与2种常用溶剂在输液泵中的配伍稳定性考察[J].中国药房,2017,28(8):1041-1044,4.基金项目
解放军第180医院医院基金课题项目(No.11D3007) （No.11D3007）
