中国药房2017，Vol.28Issue(8)：1052-1055,4.DOI:10.6039/j.issn.1001-0408.2017.08.12
我院21例利培酮致白细胞减少的不良反应报告分析
Analysis of 21 Cases of Risperidone-induced Leucocytopenia ADR Reports in Our Hospital
摘要
Abstract
OBJECTIVE:To analyze the features of risperidone-induced leucocytopenia ADR.METHODS:Twenty-one ADR cases of risperidone-induced leucocytopenia reported by our hospital were collected and analyzed during 2004-2015.The characteris tics of risperidone-induced leucocytopenia were discussed.RESULTS:Among 21 patients,there were 10 male and 11 female.The age was from 15 to 72 years old.Nine cases of patients were 31-40 years old (42.9％).Most of the original disease was schizophre nia.Incubation period of leucocytopenia caused by risperidone was (28.6 ± 21.4) d.Patients had no discomfort complain when leucocytopenia occurred.The lowest white blood cells reported was(3.1 ± 0.5)× 109 L-1.The leucocytopenia were improved after reduc tion,drug withdrawal and symptomatic treatment.CONCLUSIONS:Patients usually have no body discomfort complain when risperidone-induced leucocytopenia appears.Doctors should moniter ADR regularly,identify it earlier and treat carefully.关键词
利培酮/白细胞减少/不良反应/合理用药Key words
Risperidone/Leucocytopenia/Adverse drug reaction/Rational drug use分类
医药卫生引用本文复制引用
庄红艳,刘珊珊,果伟,马辛,郝红兵,梁海霞,王秋艳..我院21例利培酮致白细胞减少的不良反应报告分析[J].中国药房,2017,28(8):1052-1055,4.基金项目
北京市科技计划项目(No.Z151100004015180) （No.Z151100004015180）
北京市医院管理局重点医学专业发展专项经费资助项目(No.ZYL-X201403) （No.ZYL-X201403）
北京安定医院人才培养项目(No.YR-G201508) （No.YR-G201508）
