中国药房2017，Vol.28Issue(8)：1095-1097,3.DOI:10.6039/j.issn.1001-0408.2017.08.24
小剂量奥曲肽预防内镜逆行胰胆管造影术后高淀粉酶血症及急性胰腺炎的临床观察
Clinical Observation of Small Dose of Octreotide for Preventing Hyperamylasemia and Acute Pancreatitis after Endoscopic Retrograde Cholangiopancreatography
高改云 1李静 1樊宏伟 1倪猛 1孙晓1
作者信息
- 1. 南阳市中心医院消化内科,河南南阳473009
- 折叠
摘要
Abstract
OBJECTIVE:To observe clinical effects and safety of small dose of octreotide for preventing hyperamylasemia and acute pancreatitis after endoscopic retrograde cholangiopancreatography (ERCP).METHODS:One hundred and twenty ERCP pa tients were selected from our hospital during Oct.2014-Jan.2015 and then divided in to observation group and control group in accordance with random number table,with 60 cases in each group.Both groups were given Diazepam tablet 10 mg+Meperidine hydrochloride tablet 100 mg+Phenobarbital scopolamine tablet 2 tablets 0.5 h before surgery for sedation and analgesia,and routine acid suppression and anti-infective therapy.Observation group was additionally given Octreotide acetate injection 0.1 mg hypodermically and then given Octreotide acetate injection 0.1 mg immediately after surgery,8 h after surgery.The levels of serum amylase and blood glucose were observed in 2 groups,and the occurrence of postoperative complication and ADR were recorded.RESULTS:Before operation,there was no statistical significance in the levels of serum amylase and blood glucose between 2 groups (P＞ 0.05).After operation,the level of serum amylase in control group was significantly higher than in observation group,with statistical significance (P＜0.05).There was no statistical significance in blood glucose level between 2 groups after operation (P＞0.05).The incidence of hyperamylasemia and ADR in observation group was significantly lower than in control group,with statistical significance (P＜0.05),and there was no statistical significance in the incidence of acute pancreatitis between 2 groups after operation (P＞0.05).CONCLUSIONS:Small dose of octreotide can effectively reduce the level of serum amylase and the incidence of hyperamylasemia after ERCP with good safety.关键词
奥曲肽/内镜逆行胰胆管造影/小剂量/高淀粉酶血症/急性胰腺炎Key words
Octreotide/Endoscopic retrograde cholangiopancreatography/Small dose/Hyperamylasemia/Acute pancreatitis分类
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高改云,李静,樊宏伟,倪猛,孙晓..小剂量奥曲肽预防内镜逆行胰胆管造影术后高淀粉酶血症及急性胰腺炎的临床观察[J].中国药房,2017,28(8):1095-1097,3.
