中国医科大学学报2017，Vol.46Issue(1)：23-27,5.DOI:10.12007/j.issn.0258⁃4646.2017.01.005
肾小球C4d沉积为IgA肾病的预后因子
Glomerular C4d Deposition Is a Prognostic Factor for IgA Nephropathy
摘要
Abstract
Objective To investigate the significance of glomerular deposition of C4d in accessing the severity and prognosis of IgA nephropathy. Methods A total of 131 patients were recruited for the study. Immunofluorescence was used to detect the deposition of C4d in renal tissue of pa?tients with IgA nephropathy,and the relationship between C4d deposition and clinical and pathological parameters and renal remission was ana?lyzed. Results Totally 30 patients had glomerular deposition of C4d. Compared with the patients without C4d deposition,the patients with C4d deposition had significantly higher levels of serum creatinine,urinary protein excretion and C4d and higher prevalence of hypertension,but had sig?nificantly decreased levels of glomerular filtration rates. With the histopathological phenotypes segregated by Lee 's classification,the ratios of C4d deposition presented an increase(P=0.005). The patients with C4d deposition had more severe mesangial proliferation,endocapillary hypercellu?larity,segmental glomerulosclerosis and tubular?interstitial injury. The rates of renal remission were significantly lower in IgA nephropathy patients with C4d deposition than those without C4d deposition(P<0.001). Conclusion IgA nephropathy patients with C4d deposition have more se?vere clinical and pathological manifestations and lower rate of renal remission. Glomerular C4d deposition is expected to be an important pathologi?cal prognostic factor for predicting the prognosis of IgA nephropathy.关键词
补体C4d/IgA肾病/肾病预后Key words
complement C4d/IgA nephropathy/renal remission分类
医药卫生引用本文复制引用
刘林林,刘楠,王娟,朱林波,姚丽,徐天华,王力宁..肾小球C4d沉积为IgA肾病的预后因子[J].中国医科大学学报,2017,46(1):23-27,5.基金项目
国家自然科学基金青年项目(81500525) （81500525）
辽宁省自然科学基金(2014021046) （2014021046）
沈阳市科技计划(F16?206?9?04) （F16?206?9?04）
