中国医科大学学报2017，Vol.46Issue(1)：33-35,40,4.DOI:10.12007/j.issn.0258⁃4646.2017.01.007
恩替卡韦治疗后e抗原阳性慢性乙型肝炎患者Treg/Th17比率的变化及其与疗效的关系
Relationship between Changes of Treg/Th17 Ratio and Curative Effect in Patients with HBeAg?positive Chronic Hepatitis B after Receiving Entecavir
摘要
Abstract
Objective To investigate whether there are correlation among changes of Treg/Th17 ratio with virological response and serological re?sponse in patients with hepatitis B e antigen(HBeAg)?positive chronic hepatitis B(CHB)after receiving entecavir. Methods 27 patients with HBeAg?positive CHB were enrolled for the study. Peripheral blood Treg cell frequency and Th17 cell frequency,HBV DNA,alanine aminotransfer?ase levels,hepatitis B virus marker were detected before and after entecavir treatment at 4,12,24,36,and 48 weeks. Peripheral blood Treg cell frequency and Th17 cell frequency of 20 healthy volunteers were detected as well. Results Treg/Th17 ratio of patients decreased from 4 week and reached the lowest point at 12 weeks. Treg/Th17 ratio(12 weeks)of the patients who got the early virological response and HBeAg disappeared was lower than others,and the difference was statistical significant. Conclusion Treg/Th17 ratio changes in HBeAg?positive CHB patients receiv?ing entecavir antiviral treatment. Treg/Th17 ratio(12 weeks)showed significant correlation with early virological response and HBeAg disappear?ance. The changes of Treg/Th17 ratio may provide a reference of curative effect.关键词
慢性乙型肝炎/恩替卡韦/调节性T细胞/Th17细胞Key words
chronic hepatitis B/entecavir/T regulatory cell/Th17 cell分类
医药卫生引用本文复制引用
李成伟,卢丹,那妍,李岩,王本鑫,娄宪芝..恩替卡韦治疗后e抗原阳性慢性乙型肝炎患者Treg/Th17比率的变化及其与疗效的关系[J].中国医科大学学报,2017,46(1):33-35,40,4.基金项目
辽宁省科学技术计划(2013225086) （2013225086）
沈阳市卫生局科研课题(2012) （2012）
