中国医科大学学报2017，Vol.46Issue(2)：116-119,4.DOI:10.12007/j.issn.0258-4646.2017.02.005
蒙药红花对急性肝损伤大鼠TNF-α表达及肝细胞凋亡的影响
Effects of the Mongolian Medicine Carthamus Tinctorius on TNF-α Expression and Hepatocyte Apoptosis in Rats with Acute Liver Injury
摘要
Abstract
Objective To observe the protective effect of Mongolian medicine Carthamus tinctorius in acute liver injury induced by D-GlaN(D-galactosamine)in rat models. Methods The acute liver injury model was established by intragastric administration D-GlaN in rats. The levels of serum aspartate aminotransferase(AST),alanine aminotransferase(ALT),glutathione(GSH-Px),the content of tumor necrosis factor-α(TNF-α)in liver tissue and the apoptosis of hepatocytes were determined. Results Mongolian medicine safflower can significantly reduce the activity of serum ALT and AST and liver tissue GSH-Px,and the degree of cell apoptosis;however,no obvious change of the TNF-α content was observed. Conclusion The Mongolian medicine Carthamus tinctorius has protective effect in D-GlaN-induced acute liver injury rats probably via anti-oxi-dative and anti-apoptotic abilities.关键词
蒙药红花/急性肝损伤/肿瘤坏死因子α/凋亡Key words
Mongolian medicine Carthamus tinctorius/acute liver injury/TNF-α/apoptosis分类
医药卫生引用本文复制引用
刘鑫,白梅荣..蒙药红花对急性肝损伤大鼠TNF-α表达及肝细胞凋亡的影响[J].中国医科大学学报,2017,46(2):116-119,4.基金项目
内蒙古蒙医药工程技术研究院科研课题(GCY201508022) （GCY201508022）
