中国医科大学学报2017，Vol.46Issue(3)：214-218,5.DOI:10.12007/j.issn.0258-4646.2017.03.006
高尔基体磷蛋白3在肝细胞癌中的表达特点及其临床病理学意义
Expression of Golgi Phosphoprotein 3 in Human Hepatocellular Carcinoma and Its Clinicopathological Significance
摘要
Abstract
Objective To investigate the expression characteristics of Golgi phosphoprotein 3(GOLPH3)in human hepatocellular carcinoma (HCC)and explore its clinicopathological significance. Methods The expressions of GOLPH3 protein was detected in 132 cases of paired paraf-fin embedded HCC specimens and pericarcinoma tissues using immunohistochemical staining ,and the relation of the expression of GOLPH3 to clinicopathologic features was analyzed. Meanwhile,the expression and distribution of GOLPH3 in HCC cells was observed by laser confocal mi-croscopy. Results The positive expression rates of GOLPH3 in HCC and pericarcinoma tissues were 70.0%(92/132)and 42.4%(56/132) (P<0.001),respectively. The incidence of portal vein tumor thrombus in high and low GOLPH3 expression groups of HCC were 21.2%(14/66) and 6.1%(4/66)(P<0.05),respectively. The expression rate of GOLPH3 in HCC was significantly higher than that in pericarcinoma tissues, and the expression of GOLPH3 in HCC was positively related to portal vein tumor thrombus. In addition ,GOLPH3 was mainly expressed in cyto-plasm of HCC cells,and there was also scattered distribution in the nucleus. Conclusion GOLPH3 acts as an oncogene and may play vital roles in the carcinogenesis and development of HCC.关键词
肝细胞癌/高尔基体鳞蛋白3/免疫组化/免疫荧光Key words
hepatocellular carcinoma/Golgi phosphoprotein 3/immunohistochemistry/immunofluorescence分类
医药卫生引用本文复制引用
张城硕,陈保民,焦奥,孙宁,张佳林..高尔基体磷蛋白3在肝细胞癌中的表达特点及其临床病理学意义[J].中国医科大学学报,2017,46(3):214-218,5.基金项目
辽宁省自然科学基金(201602874) （201602874）
