中国药理学通报2017，Vol.33Issue(3)：301-305,5.DOI:10.3969/j.issn.1001-1978.2017.03.002
以Nrf2为靶点防治肾脏疾病的研究进展
Research on preventative role of Nrf2 in kidney diseases
摘要
Abstract
Nrf2,a key transcriptional factor in regulating endog-enous antioxidant signaling pathway,maintains the redox bal-ance by controlling the expression of a battery of antioxidant en-zymes,phase-Ⅱ detoxification enzymes and phase-Ⅲ transport-ers.Furthermore,Nrf2 regulates inflammation.Recent resear-ches have confirmed that Nrf2 provides a vital physiological role in kidney diseases,activation of Nrf2 enhances the antioxidant and anti-inflammatory ability in cellular and tissue levels,thusalleviates renal injury.Here,this article aims to summarize the protective effect of Nrf2 on various models of kidney impairment and explore the potential of Nrf2 as a therapeutic target to pre-vent kidney diseases.关键词
Nrf2/氧化应激/NF-κB/肾缺血/再灌注/急性肾毒性/慢性肾脏疾病/糖尿病肾病Key words
Nrf2/oxidative stress/NF-κB/renal ischemia-reperfusion injury/acute kidney injury/chronic kidney disease分类
医药卫生引用本文复制引用
曹思思,颜苗,张毕奎,蒋云生,樊新荣..以Nrf2为靶点防治肾脏疾病的研究进展[J].中国药理学通报,2017,33(3):301-305,5.基金项目
国家自然科学基金资助项目(No 81202985,81573686, 81373708) （No 81202985,81573686, 81373708）
