中国药理学通报2017，Vol.33Issue(3)：305-308,4.DOI:10.3969/j.issn.1001-1978.2017.03.003
转录因子EB与帕金森病
Transcription factors EB and Parkinson's disease
摘要
Abstract
Autophagy is a powerful process for removing such proteins and for maintaining homeostasis.However,autophagy dysfunction has also been implicated in the pathogenesis of vari-ous neurodegenerative diseases,including Parkinson 's disease (PD).Recent studies have shown that TFEB could regulate au-tophagy and lysosome function through regulating the expressionof the relatedgenes.Thus,TFEB plays a key role in the occur-rence of Parkinson's disease.Therefore,this article will make a review of the regulatory mechanism of TFEB and its role in Par-kinson's disease.关键词
转录因子EB/帕金森病/自噬/溶酶体/α-突触核蛋白/mTORKey words
transcription factors EB/Parkinson's disease/auto-phagy/lysosome/α-synuclein/mTOR分类
医药卫生引用本文复制引用
郝新梅,李玉娟..转录因子EB与帕金森病[J].中国药理学通报,2017,33(3):305-308,4.基金项目
中国中医科学院自主课题项目(No zz2015003) （No zz2015003）
