中国药理学通报2017，Vol.33Issue(3)：312-316,5.DOI:10.3969/j.issn.1001-1978.2017.03.005
低剂量甲氨蝶呤的抗炎作用机制及其在脊髓损伤中应用
Anti-inflammatory mechanism of low dose methotrexate and its application in spinal cord injury
摘要
Abstract
Methotrexate (MTX)has dual effects of anti-inflam-matory and immune suppression,and its pharmacological mecha-nism is complex,diverse and synergistic.This paper summari-zes the main anti-inflammatory mechanism of low-dose MTX,in-cluding inhibition of JAK/STAT pathway,inhibition of inflam-matory reaction and immune response,increasing the accumula-tion of adenosine and the function of intracellular metabolites (methotrexate polyglutamate).In addition,low-dose MTX can inhibit oxidation by decreasing the level of lipid peroxidation, suppress the inflammatory response to secondary spinal cord in-jury,reduce spinal cord ischemia reperfusion injury and neuro-pathic pain,thus playing a neuroprotective role by a series of pharmacological mechanism.The anti-inflammatory mechanism of low-dose MTX and its application in spinal cord injury were reviewed,to guide the further research on the anti-inflammatory effect of MTX,and provide a theoretical basis for new drugs for clinical treatment of spinal cord injury.关键词
甲氨蝶呤/低剂量/脊髓损伤/抗炎作用/JAK/STAT通路/氧化反应/腺苷Key words
methotrexate/low dose/spinal cord injury/anti-in-flammatory effect/JAK/STAT pathway/oxidative reaction/adeno-sine分类
医药卫生引用本文复制引用
原琴琴,周玉敏,顾兵,刘建涛,李华南,余兆仲..低剂量甲氨蝶呤的抗炎作用机制及其在脊髓损伤中应用[J].中国药理学通报,2017,33(3):312-316,5.基金项目
国家自然科学基金资助项目(No 30960448) （No 30960448）
江西省自然科学基金资助项目(No 20142BAB205023) （No 20142BAB205023）
江西省教育厅科学技术研究项目(No GJJ14603) （No GJJ14603）
江西科技师范大学第十届本科生科研基金项目 （）
