中国药理学通报2017，Vol.33Issue(3)：384-388,5.DOI:10.3969/j.issn.1001-1978.2017.03.018
CJ016对人肺癌裸鼠移植瘤的抑制活性研究
Study of CJ016 in treatment of lung cancer
摘要
Abstract
Aim Tostudythetherapeuticeffectof CJ016 on human lung cancer model and the mecha-nism.Methods Anexperimentalhumanlungadeno-carcinoma model of A549 was set up to investigate the anti-tumor effect of CJ016,while the effect of angio-genesis and apoptosis in tumor were detected.Results In vitro,the cell proliferation was inhibited signifi-cantly by CJ016,and the value of IC50 was 34. 22 nmol ·L-1 .In vivo,the tumor inhibition rate and T/C%value were 70. 08%and 27. 75%,respectively,at the dose of 20 mg·kg-1 .Meanwhile,CJ016 could reduce the expression of CD31 and promote the apoptosis of tumorcells.Conclusion CJ016caninhibitthegrowth of A549 cells,and the possible mechanism may be re-lated to the reduction of angiogenesis and inducing tumor cell apoptosis.关键词
肺癌/作用机制/CJ016/A549/IC50/CD31/细胞凋亡Key words
lung cancer/mechanism/CJ016/A549/IC50/CD31/apoptosis分类
医药卫生引用本文复制引用
甘萍,谭永红,金伟华,王玲洁,于波涛..CJ016对人肺癌裸鼠移植瘤的抑制活性研究[J].中国药理学通报,2017,33(3):384-388,5.基金项目
国家自然科学基金青年基金资助项目(No 81402493) （No 81402493）
