中国医学装备2017，Vol.14Issue(3)：147-150,4.DOI:10.3969/J.ISSN.1672-8270.2017.03.041
针刺改善阿尔茨海默病模型动物记忆障碍的机制研究
The mechanism of acupuncture improving memory dysfunction in AD animal model
摘要
Abstract
Alzheimer's disease (AD), also called senile dementia, has been the third main disease threatened human health. As major clinical manifestation in AD, memory dysfunction could be treated well by acupuncture which has distinctive advantage for this kind of disease. Recently, there are many studies reported that acupuncture improved memory in AD model. In combined with our researching progress, we reviewed mechanisms of acupuncture for improving memory dysfunction in AD models in terms of reducing Aβ and tau level, enhancing synaptic transmission, promoting cholinergic neurons activity, increasing monoamine neurotransmitter level, antioxidant, protecting neurons from injury and promoting brain neurotrophic factors expression. Based on above research results, acupuncture is effective for improving memory dysfunction in AD animal model.关键词
针刺/老年性痴呆/记忆障碍/阿尔茨海默病Key words
Acupuncture/Senile dementia/Memory dysfunction/Alzheimer's disease分类
医药卫生引用本文复制引用
张博,李炎,张雨薇,刘学伟,孙忠人,黄树明..针刺改善阿尔茨海默病模型动物记忆障碍的机制研究[J].中国医学装备,2017,14(3):147-150,4.基金项目
国家自然科学基金青年科学基金(81603321)"基于突触后膜受体调控的开心散改善Aβ所致突触可塑性抑制的机制研究" （81603321）
黑龙江省自然科学基金(H2016072)"开心散改善Aβ所致记忆障碍的突触机制研究" （H2016072）
黑龙江省博士后资助项目(LBH-Z13200)"针刺补肾改善性腺切除动物记忆障碍的机制研究" （LBH-Z13200）
黑龙江中医药大学科研基金(2015bs04)"开心散改善神经元信息传递可塑性的突触后膜机制研究" （2015bs04）
