中国药业2017，Vol.26Issue(4)：19-21,3.DOI:10.3969/j.issn.1006-4931.2017.04.005
呋塞米片质量标准提高研究
Improvement of Quality Standard for Furosemide Tablets
么世英1
作者信息
- 1. 内蒙古自治区呼和浩特市食品药品检验所,内蒙古呼和浩特 010020
- 折叠
摘要
Abstract
Objective To establish a UHPLC method for quantity determination of Furosemide Tablets. Methods Shim-pack XR-ODSⅢ C18 column was adopted. The mobile phase consisted of water-tetrahydrofuran-glacial acetic acid (63 :37 :1),the detection wavelength was 272 nm and the flow rate was 0. 2 mL/min. Results The regression equation was Y=6. 92 × 106 X-2. 88 × 104,and the furosemide concentration was linear in the range of 0. 019-0. 761 μg (r=0. 9999),the average recovery was 100. 90%,RSD was 1. 56%(n=6). Conclusion The UHPLC method can increase the analysis speed and improve analysis effect on the condition that separation effect had not been influenced. which can be used as one of the quality control measures for Furosemide Tablets.关键词
呋塞米/超高效液相色谱法/质量标准Key words
furosemide/UHPLC/quality control分类
医药卫生引用本文复制引用
么世英..呋塞米片质量标准提高研究[J].中国药业,2017,26(4):19-21,3.
