中国中医药信息杂志2017，Vol.24Issue(4)：24-28,5.DOI:10.3969/j.issn.1005-5304.2017.04.007
维药成熟与清除疗法对咸味黏液质型银屑病血清代谢组学的影响
Effects of Uyghur Medicine Munziq and Mushil's Therapy on Serum Metabolomics of Abnormal Phlegmatic Type Psoriasis
摘要
Abstract
Objective To investigate the effects of Uyghur Medicine Munziq and Mushil's therapy on the metabolic changes in serum of patients with abnormal phlegmatic type psoriasis by NMR based metabonomic method.Methods NMR technology were used to detect serum of patients with abnormal phlegmatic type psoriasis before and after treated by Munzig and Mushil's therapy. OPLS-DA was used to study the differences of serum endogenous compounds between pre-treatment, post-treatment and normal control groups.Results Compared with normal control group, levels of some metabolites including VLDL, isoleucine, leucine, valine, lactate, threonine, alanine, methionine, acetic acid, glycoprotein, acetylcysteine, glutamine, acetone, carnitine, creatine, malonic acid,β-glucose,α-glucose, inositol, choline, glycine and LDL in serum increased significantly, while levels of tyrosine, histidine, and formic acid decreased significantly (P<0.05). Compared with before treatment, levels ofβ-glucose andα-glucose decreased significantly after treatment, with statistical significance (P<0.05).Conclusion The levels of amino acid metabolism, lipid metabolism and glucose metabolism in patients with abnormal phlegmatic type psoriasis are abnormal to different degrees. The treatment of Uyghur Medicine Munziq and Mushil's therapy may be achieved through regulating the disorder of glucose metabolism in the patient.关键词
成熟与清除疗法/咸味黏液质/银屑病/代谢组学Key words
Munziq and Mushil's therapy/abnormal phlegm/psoriasis/metabonomics分类
医药卫生引用本文复制引用
努尔比艳木·阿布都热合曼,塔依尔·吐尔松,买吾拉尼江·依孜布拉,马丽娜,毛吾丽旦木·迪力夏提,阿米尔·艾力,努尔买买提·艾买提..维药成熟与清除疗法对咸味黏液质型银屑病血清代谢组学的影响[J].中国中医药信息杂志,2017,24(4):24-28,5.基金项目
新疆维吾尔自治区青年科技科研人才培养工程项目(2014721010) （2014721010）
