中国卒中杂志2017，Vol.12Issue(2)：105-111,7.DOI:10.3969/j.issn.1673-5765.2017.02.003
皮质下血管性认知障碍患者弥散张量成像和脑血流量的研究
Diffusion Tensor Imaging and Cerebral Blood Flow Study of Patients with Subcortical Vascular Cognitive Impairment
摘要
Abstract
Objective To investigate the correlation between white matter integrity, cerebral blood lfow and cognitive impairment in patients with cerebral small vessel disease (CSVD). <br> Methods A total of 58 patients with CSVD were consecutively recruited and categorized into 3 groups, no cognitive mild impairment (NCI,n=11) group, vascular mild cognitive impairment (VaMCI,n=29) group and vascular dementia (VaD,n=18) group. White matter diffusion tensor imaging (DTI) parameters including mean diffusivity (MD) and fractional anisotropy (FA) of periventricular (PV) and corona radiate (CR) regions were evaluated. Cerebral blood lfow (CBF) were also measured by CT perfusion (CTP) imaging at these areas. Correlation between DTI parameters, CBF and cognitive function were then analyzed. <br> Results① CBF and MD within PV region differed signiifcantly among the three groups (P<0.01), where MD was significantly correlated with CBF as well as with the executive function (mean P<0.01). However, there was no correlation between CBF and cognitive function. FA showed no statistical difference among the groups. There was no correlation between FA with CBF or cognitivefunction.② CBF, MD and FA within CR region showed no statistical differences among the three groups. However, MD within CR region was found to be correlated with the attention executive function (P<0.05). There was no statistically signiifcant correlation between CBF with DTI parameters and cognitive function. <br> Conclusion White matter dysintegrity within PV region is an important imaging marker of cognitive impairment in patients with CSVD. Hypoperfusion may play an important role in PV white matter dysfunction.关键词
脑小血管病/血管性认知障碍/弥散张量成像/脑血流量Key words
Cerebral small vessel disease/Vascular cognitive impairment/Diffusion tensor imaging/Cerebral blood lfow引用本文复制引用
支楠,徐群,柴文,卢东,赵薇,耿介立,糜建华,俞羚,曹雯炜,周滟..皮质下血管性认知障碍患者弥散张量成像和脑血流量的研究[J].中国卒中杂志,2017,12(2):105-111,7.基金项目
科技部国家重点研发项目（2016YFC1300600）上海市科委西医引导项目 （）
