中国卒中杂志2017，Vol.12Issue(2)：112-118,7.DOI:10.3969/j.issn.1673-5765.2017.02.004
阿替普酶静脉溶栓治疗急性后循环缺血性卒中患者的预后相关因素分析
Correlation Factors Analysis for the Prognosis in Patients with Posterior Circulation Infarction after Intravenous Thrombolysis with Alteplase
摘要
Abstract
Objective To investigate the correlation factors for the prognosis in patients with posterior circulation infarction after intravenous thrombolysis with alteplase. <br> Methods The patients with posterior circulation infarction at 0-4.5 h after onset were selected and divided into alteplase intravenous thrombolysis group and non-intravenous thrombolysis group. General demographic data and basic information were recorded and evaluated with National Institutes of Health Stroke Scale (NIHSS) score. The time from onset to thrombolysis and NIHSS score at 24 h after thrombolysis were also recorded. The outcome indexes included 90-day functional outcomes (by modiifed Rankin Scale, mRS), symptomatic intracranial hemorrhage (SICH) and mortality. Logistic regression analysis was used to evaluate the indexes in predicting the 3-month outcome of patients. <br> Results A total of 116 patients with acute posterior circulation infarction were included. Among which, 84 (72.4%) were in intravenous thrombolysis group and 32 were in non-thrombolysis group. There were 53 cases (63.1%) in good prognosis group and 31 cases (36.9%) in poor prognosis group.Whereby, there were 6 cases of hemorrhage transformation (7.1%), and 3 cases of symptomatic intracranial hemorrhage (3.5%). In non-intravenous thrombolysis group, there were 12 cases of good prognosis at month 3 (37.5%) and 20 cases of poor prognosis (62.5%). Whereby, there were 5 cases of hemorrhage transformation (15.6%), 3 cases of symptomatic intracranial hemorrhage (9.3%) and 3 cases of deaths (9.3%). Logistic regression analysis showed that the age, thrombolysis time and the NIHSS score, hypertension were the associated with the poor prognosis of posterior circulation infarction patients after intravenous thrombolysis at 90 d (P<0.05). Compared with non-intravenous thrombolysis group, patients in intravenous thrombolysis group had a signiifcant improvement of favorable outcome and lower mortality, however, there was no signiifcant difference in morbidity of SICH between the two groups. <br> Conclusion Early intravenous thrombolysis has certain significant influence on improving the short-term prognosis in patients with posterior circulation infarction.关键词
急性缺血性卒中/后循环缺血/静脉溶栓/预后Key words
Ischemic stroke/Posterior circulation infarction/Thrombolytic therapy/Prognosis引用本文复制引用
车锋丽,陈胜云,赵性泉,杜会山,魏建朝..阿替普酶静脉溶栓治疗急性后循环缺血性卒中患者的预后相关因素分析[J].中国卒中杂志,2017,12(2):112-118,7.基金项目
北京市医院管理局“登峰”人才培养计划（DFL20150501）北京市卫生系统高层次卫生技术人才培养计划“学科带头人”（2014-2-010）北京市科学技术委员会资助 （）
