中国卒中杂志2017，Vol.12Issue(2)：119-123,5.DOI:10.3969/j.issn.1673-5765.2017.02.005
帕罗西汀对缺血性卒中不伴抑郁患者神经功能恢复的临床疗效观察
Clinical Effect Observation of Paroxetine on the Neural Function Recovery in Ischemic Stroke Patients without Depression
潘小玲 1程兴 1胡传琛 1王建伟 1邵慧军 1傅亚明 1孔慧梅 1陈红芳1
作者信息
- 1. 321000 金华浙江大学金华医院神经内科
- 折叠
摘要
Abstract
Objective To investigate the effects of paroxetine on neural function recovery in ischemic stroke patients without depression. <br> Methods A total of 167 acute ischemic stroke hospitalized patients without depression were selected and divided into the treatment group and the control group randomly. All patients received the conventional secondary prevention and rehabilitation training of ischemic stroke, the treatment group patients were additionally treated with paroxetine (10 mg/d in the ifrst week, and then 20 mg/d) for 3 months, and observed for 6 months. The Fugl-Meyer Motor Scale (FMMS), Montreal Cognitive Assessment (MoCA) and Hamilton Depression Scale (HAMD) were used at day 0, day 15, day 90 and day 180 (90 days after the treatment stopped) after the start of the study, then a comparison about the scores between the two groups were made. <br> Results There were statistical differences in the FMMS and MoCA scores between the treatment and control group at day 90 and day 180 after the start of the study (P<0.05), whereas there were no statistical differences in the FMMS and MoCA scores between the two groups at day 15 (P>0.05). There were statistical differences in the HAMD scores between the two groups at day 180 afterthe start of the study (P<0.05), whereas there were no statistical differences in the HAMD scores between the two groups at day 15 and day 90. <br> Conclusion Paroxetine could improve motor and cognitive function recovery in acute ischemic stroke patients without depression. Moreover, it would reduce the occurrence of depression after stroke.关键词
缺血性卒中/帕罗西汀/神经功能恢复Key words
Ischemic stroke/Paroxetine/Neural function recovery引用本文复制引用
潘小玲,程兴,胡传琛,王建伟,邵慧军,傅亚明,孔慧梅,陈红芳..帕罗西汀对缺血性卒中不伴抑郁患者神经功能恢复的临床疗效观察[J].中国卒中杂志,2017,12(2):119-123,5.
