中国卒中杂志2017，Vol.12Issue(2)：132-142,11.DOI:10.3969/j.issn.1673-5765.2017.02.007
脑小血管病和脑微循环研究进展
Progress in Research of Cerebral Small Vessel Disease and Cerebral Microcirculation
摘要
Abstract
Cerebral small vessel disease (CSVD) refers to a syndrome caused by pathophysiologic changes of cerebral microcirculation (including cerebral small vessels or the microvessels) and it can result in acute stroke, cognitive impairment, and many other clinical manifestations. Arteriolosclerosis, embolism, endothelial dysfunction, blood-brain barrier damage, amyloid deposition, cerebral hypoperfusion and venous collagenosis of cerebral microcirculation are thought to be closely associated with the pathogenesis of CSVD, which provide new strategies for its treatment. A definite diagnosis of this disease relies on biopsy, which usually indicates that it is the end stage of the disease. Also, it is difficult to obtain histopathologic materials, so clinical diagnosis is mainly dependent on neuroimaging. This review discusses the manifestations, classification, pathophysiologic mechanisms and clinical examinations related to cerebral microcirculation, so as to ifnd new diagnostic and therapeutic strategies for cerebral small vessel disease.关键词
脑小血管病/脑微循环/血脑屏障/病理生理Key words
Cerebral small vessel disease/Cerebral microcirculation/Blood-brain barrier/Pathophysiology引用本文复制引用
刘品一,黄丽丽,徐运..脑小血管病和脑微循环研究进展[J].中国卒中杂志,2017,12(2):132-142,11.基金项目
江苏省科技厅医学重点项目 （）
