摘要
Abstract
Objective To study the correlative factors of the cerebral venous sinus thrombosis (CVST) in early-onset seizures. Methods The patients with cerebral venous sinus thrombosis were selected as subjects and were divided into early onset epilepsy group and the control group according to the criteria of whether there were epileptic seizures within 2 weeks after the onset. Retrospective analysis of patients was made upon clinical data including acute clinical manifestation, imaging and electroencephalogram (EEG), etc. Single factor analysis and binary logistic regression analysis were made to study the factors that might inlfuence the early onset of epilepsy of CVST. Results A total of 64 patients with CVST were enrolled, among whom, there were 19 cases in early onset epilepsy group (29.7%) and 45 cases in the control group (70.3%). By the single factor analysis of early-onset epilepsy group, the puerperal women during pregnancy (52.6%vs 20.5%, P=0.01), disturbance of consciousness (31.6%vs 8.89%,P=0.02), the multiple lobes lesion (52.6%vs 24.4%,P=0.03), cerebral infarction merger of vein bleeding (52.6%vs 11.1%,P=0.01), abnormal EEG (73.7%vs 46.6%,P=0.01) were significantly higher than that of control group, with significant difference statistically. Binary logistic regression analysis showed that more cerebral lobe lesions [(odds ratio (OR) 12.89, 95% conifdence interval (CI) 2.12-78.41], cerebral infarction merger of vein bleeding (OR 12.92, 95%CI 12.92-99.25), EEG anomalies (OR 2.19, 95%CI 2.19-4.49) were risk factors for early onset seizures in CVST. Conclusion Multiple cerebral lobe lesions, vein cerebral infarction with bleeding and abnormal electroencephalogram (EEG) were independent risk factors for CVST early-onset seizures.关键词
脑静脉窦血栓形成/癫痫/痫性发作Key words
Cerebral venous sinus thrombosis/Epilepsy/Early-onset seizures
