中华耳科学杂志2017，Vol.15Issue(1)：99-104,6.DOI:10.3969/j.issn.1672-2922.2017.01.019
内淋巴积水动物模型研究进展
Research Progress in Animal Models of Endolymphatic Hydrops
摘要
Abstract
Meniere's disease is an inner ear disorder characterized by recurrent episodes of rotational vertigo, fluc-tuating sensorineural hearing loss, and tinnitus, with or without ear fullness. The pathogenesis of Meniere's disease is unclear. The typical pathological feature of Meniere's disease is endolymphatic hydrops, although the precise mecha-nism is not fully understood. Studies have confirmed that endolymphatic sac plays an important role in endolymph vol-ume regulation, and the cascade of histopathological and electrophysiological changes associated with chronic endolym-phatic hydrops. Using the animal model of endolymphatic hydrops to investigate variable aspects of the disease (e.g., how hydrops occurs, its relationship with pathology and electrophysiology changes, how it affects the inner ear func-tion, and so on) would be helpful to guide the treatment of the disease. The periodic episodes of Meniere's disease sug-gest that controlling the endolymphatic hydrops might be the key to maintain the inner ear homeostasis and to avoid pro-gression of the disease.关键词
梅尼埃病/内淋巴积水/动物模型Key words
Meniere's Disease/Endolymphatic hydrops/Animal model分类
医药卫生引用本文复制引用
丁玉静,刘俊秀,马芙蓉..内淋巴积水动物模型研究进展[J].中华耳科学杂志,2017,15(1):99-104,6.基金项目
国家自然科学基金资助项目(21272018) （21272018）
国家重大研究计划资助项目(91213305),首都卫生发展科研专项项目(2016-2-4094). Natural science foundation of China(21272018) （91213305）
National major research program(91213305) （91213305）
Capital health devel-opment and scientific research project(2016-2-4094). （2016-2-4094）
