浙江医学2017，Vol.39Issue(1)：12-15,19,5.
非体外循环冠状动脉旁路移植术前不停用阿司匹林安全性的Meta分析
Safety of preoperative aspirin use in patients undergoing off-pump coronary artery bypass grafting: a meta-analysis
摘要
Abstract
Objective To systematically assess the safety of preoperative aspirin use in patients undergoing off-pump coronary artery bypass grafting (OPCABG).Methods Databases including Pubmed,Web of Science,COCHRANE LIBRARY,WanFang Data and CNKI Data were searched from inception to May 2016 for clinical studies for OPCABG without stopping pre-operative aspirin use.According to the inclusion criterion,relevant articles were screened.The data were extracted,the quality was assessed,and meta-analysis was performed using Rev Man 5.2.Results One randomized controlled trial (RCT) and 5 retrospective studies involving 4368 patients were included.The result of meta-analyses showed that there were no significant differences in volume of 24-h drainage(MD=32.83,95％CI:-7.92～73.58,P=0.11),volume of total drainage (MD=19.07,95％CI:-30.86～69.01,P=0.45),volume of transfusion red blood cells (MD=0.18,95％CI:-0.15～0.50,P=0.28),volume of transfusion of fresh frozen plasma(MD=-3.30,95％CI:-44.84～38.24,P=0.88),ventilation time(MD=-0.07,95％CI:-0.86～0.71,P=0.85),reoperation due to bleeding (OR=1.04,95％CI:0.52～2.08,P=0.91) between discontinued aspirin group and continued aspirin group.Conclusion Current evidence indicates that preoperative continuation of aspirin therapy dose not increase bleeding related complications,or extend ventilation time in patients with OPCABG.关键词
非体外循环冠状动脉旁路移植术/阿司匹林/Meta分析Key words
Off-pump coronary artery bypass grafting/Aspirin/Meta analysis引用本文复制引用
陈绍稀,吕晶,吴昌昊,何仁良..非体外循环冠状动脉旁路移植术前不停用阿司匹林安全性的Meta分析[J].浙江医学,2017,39(1):12-15,19,5.基金项目
浙江省卫生厅一般研究项目(2016KYA005) （2016KYA005）
