浙江医学2017，Vol.39Issue(1)：28-31,4.
老年女性服用钙复方制剂与BMD、BTMs及25(OH)D水平的相关性研究
Bone mineral density, bone turnover markers and 25-hydroxy vitamin D3 levels in elderly women taking vitamin D & calcium compound preparation
摘要
Abstract
Objective To investigate the bone mineral density (BMD),bone turnover markers (BTMs) and 25-hydroxy vitamin D3 [25(OH)D] levels in elderly women taking vitamin D & calcium compound preparation(calcium compound).Methods Selected the old female total 1305 women aged 65-93 years were enrolled in the study,including 384 cases taking calcium compound in the past 6 months (study group) and 921 cases not taking calcium compound (control group).The levels of BMD,procollagen type Ⅰ carboxy terminal peptide sequence specific beta (CTX),total collagen type Ⅰ N-terminal propeptide(P1NP),osteocalcin (OC),25 (OH)D and parathyroid hormone (PTH) were detected and compared between two groups,and also compared between two groups in different age groups (65-74,75-84 and 85-93).The reasons for failed adherence of administration were analyzed.Results The incidence of osteoporosis in study group was 44.53％,which was significantly lower than that in the control group (P＜0.01).Compared with the control group,the levels of BTMs (CTX,P1NP,OC) in the study group were lower (P＜0.01) and that of 25(OH) D was higher(P＜0.01).The differences of BTMs and 25(OH)D levels between two groups in all three age groups were statistically significant(P＜0.05).The common causes of failed adherence of medication were'no use or even harmful','no knowledge or no order from doctor','forget or no bother'and'causing epigastric discomfort or constipation,or too hard to swallow',accounting for 25.08％,19.54％,15.85％ and 14.88％,respectively.Conclusion Taking vitamin D & calcium compound preparation is of help to decrease the BTMs,increase serum 25 (OH) D levels,and reduce the incidence of osteoporosis in elderly women.关键词
骨质疏松症/骨密度/骨转换标志物/25-羟基维生素D3/老年女性Key words
Osteoporosis/Bone mineral density/Bone turnover markers/25-hydroxy vitamin D3/Elder woman引用本文复制引用
夏清,边平达,寿张轩,陈锦平..老年女性服用钙复方制剂与BMD、BTMs及25(OH)D水平的相关性研究[J].浙江医学,2017,39(1):28-31,4.基金项目
浙江省医药卫生平台重点资助项目(2016ZDA002) （2016ZDA002）
浙江省人民医院优秀青年人员科研启动基金(zry2015C002) （zry2015C002）
