浙江医学2017，Vol.39Issue(1)：40-42,45,4.
单唾液酸四己糖神经节苷脂联合头部亚低温治疗对新生儿缺氧缺血性脑病的疗效观察
Monosialotetrahxosy1 ganglioside combined with head mild hypothermia for neonatal hypoxic-ischemic encephalopathy
陈茜娜 1徐棉 1林振浪 2黄雨茅 3金伟敏3
作者信息
- 1. 温州市中心医院新生儿科
- 2. 温州医科大学附属第二医院新生儿科
- 3. 瑞安市人民医院新生儿科
- 折叠
摘要
Abstract
Objective To evaluate the efficacy of monosialotetrahxosy1 ganglioside (GM1) combined with head mild hypothermia in treatment of neonatal hypoxic-ischemic encephalopathy(HIE).Methods Eighty seven newborns with moderate to severe HIE were randomly assigned into three groups to receive routine treatment (n=30),hypothermia treatments (n=27) or GM1 combined with hypothermia treatments (n=30).All patients received treatment within 6h after birth.Neonatal behavioral neurological assessment (NBNA) were conducted at postnatal age 1-3d,4-6d and 7-10d.The concentration of nitrite (NO2-),nitrotyrosine(NT) and superoxide dismutase (SOD) levels in plasma were assessed 7 days after treatment.Results The overall efficacy in GM1 combined with hypothermia group(73.3％) was significantly higher than that in hypothermia(55.5％) and routine treatment(53.3％) group(P＜0.01).No significant difference of NBNA scores at postnatal age 1-3d was observed among three groups (P ＞0.05).NBNA scores at 4-6 days and 7-10 days after birth in GM1 combined with hypothermia group were higher than those in routine and hypothermia treatment groups (all P＜0.05).The level of NO2-and NT in GM1 combined with hypothermia group were lower and the level of SOD was higher than those in routine treatment group (all P＜0.05).Conclusion GM1 combined with head mild hypothermia can effectively treat neonatal hypoxic-ischemic encephalopathy,which may be associated with the attenuation of nitrosative stress and lipid peroxidation by enhancing the activity of anti-oxidation enzyme.关键词
单唾液酸四己糖神经节苷脂/头部亚低温/缺氧缺血性脑病Key words
GM1/Head mild hypothermia/Hypoxic-ischemic encephalopathy引用本文复制引用
陈茜娜,徐棉,林振浪,黄雨茅,金伟敏..单唾液酸四己糖神经节苷脂联合头部亚低温治疗对新生儿缺氧缺血性脑病的疗效观察[J].浙江医学,2017,39(1):40-42,45,4.
