浙江医学2017，Vol.39Issue(2)：85-88,4.
SU5416对小鼠急性肺损伤后肺纤维化的影响研究
VEGF receptor inhibitor SU5416 attenuates pulmonary fibrosis in mice with acute lung injury
摘要
Abstract
Objective To investigate the effect of VEGF receptor inhibitor SU5416 on pulmonary fibrosis after acute lung injury in rats.Methods Ninety C57BL/6 mice were randomly divided into three groups (n=30 in each group).Lung injury was induced by injection of lipopolysaccharide (LPS) via caudal vein in model group and intervention group;mice in control group were injected with 0.5ml normal saline instead.SU5416 (50mg/kg) was given to mice in intervention group and the same volume of normal saline was given to mice in control group and model group.Mice were sacrificed at d7,d14 and d28.Pathological changes of the lung tissue and ALl score and hydroxyprolline contents were examined.The expression of VEGF and CD31 were measured by immunohistochemistry.Results ALl score,the expression of VEGF and CD31,and hydroxyprolline contents in model group and intervention group were higher than those in control group.Compared with model group,these changes were attenuated significantly in intervention group.Conclusion Administration of SU5416 can attenuate LPS-induced pulmonary fibrosis in mice,which is associated with the down-regulation of VEGF and CD31 expression.关键词
血管内皮生长因子受体抑制剂/急性肺损伤/肺纤维化/VEGF/CD31Key words
Vascular endothelial growth factor receptor inhibitor/Acute lung injury/Pulmonary fibrosis/VEGF/CD31引用本文复制引用
黄旭晴,徐长青,童岳阳..SU5416对小鼠急性肺损伤后肺纤维化的影响研究[J].浙江医学,2017,39(2):85-88,4.基金项目
浙江省公益性技术应用研究计划项目(2015C33258) （2015C33258）
杭州市社会发展自主申报项目(20160533B18) （20160533B18）
杭州市卫生科技计划项目(2011A017) （2011A017）
