浙江医学2017，Vol.39Issue(3)：173-176,4.
献血人群中HCV感染与HLA-Ⅱ类基因的相关性研究
Association of HLA-Ⅱ alleles with hepatitis C virus infection in blood donors
摘要
Abstract
Objective To investigate the association of HLA-Ⅱ alleles with hepatitis C virus (HCV) infection in Zhejiang blood donors.Methods Forty five HCV positive cases were detected by blood nucleotide screening among blood donors in Zhejiang Provincial Blood Center from October 2011 to October 2013.HLA typing was performed with polymerase chain reaction analysis with sequence-based typing(PCR-SBT) in 45 HCV infected blood donors;the healthy population was used for reference,including 8333 cases for HLA-DRB1 and 72 case for HLA-DQB1.Results The polymorphisms of HLA-Ⅱ alleles DRB1*01:02 (OR=23.4,95％CI:2.89-189.1,P=0.0394),DRB1*13:01 (OR=5.60,95％CI:1.74-18.00,P=0.0095),DQB1*03:03 (OR=0.45,95％CI:0.21-0.94,P=0.0402,),DQB1*06:01 (OR=2.47,95％CI:1.05-5.83,P=0.0456) were significantly associated with HCV infection among blood donors.Conclusion Our data suggest that certain HLA-Ⅱ alleles are associated with HCV infection as a host genetic factor among the Zhejiang blood donors.关键词
献血人群/HCV/HLA-Ⅱ类基因Key words
Blood donors/Hepatitis C Virus/HLA-Ⅱ alleles引用本文复制引用
戴兵,徐罡,王芳,何吉,朱发明..献血人群中HCV感染与HLA-Ⅱ类基因的相关性研究[J].浙江医学,2017,39(3):173-176,4.基金项目
浙江省医药卫生项目(2016KYA070、2015KYB100) （2016KYA070、2015KYB100）
