肿瘤防治研究2017，Vol.44Issue(3)：231-235,5.DOI:10.3971/j.issn.1000-8578.2017.03.015
基于能量代谢的抗肿瘤药物研究进展
Research Progress of Tumor Metabolism for Antitumor Drugs
摘要
Abstract
In 1920 Otto Warburg firstly described that even in the presence of ample oxygen,cancer cells prefer to metabolize glucose by glycolysis,which named as "Warburg effect".There are growing evidence supporting that the glycolysis pathway of cancer cells is closely associated with the tumorigenesis and development.The drugs targeting glycolytic enzymes and transporters can have an obviously anti-tumor effect by inducing tumor cells cycle arrest,apoptosis,regulating the autophagy of cancer cells and inhibiting the metastasis of the tumor.Many glycolytic enzymes and transporters can be suitable candidate targets for cancer therapy.The review is focused on the inhibitors of glycolysis reported in recent years,summerizes and outlooks the anti-tumor effect of these drugs.关键词
能量代谢/糖酵解/抗肿瘤Key words
Metabolism/Glycolysis/Anti-tumor分类
医药卫生引用本文复制引用
侯晓莹,杜鸿志,袁胜涛..基于能量代谢的抗肿瘤药物研究进展[J].肿瘤防治研究,2017,44(3):231-235,5.基金项目
国家高技术研究发展计划(2014AA022208) （2014AA022208）
