安徽医科大学学报2017，Vol.52Issue(3)：412-416,5.DOI:10.19405/j.cnki.issn1000-1492.2017.03.024
化疗后CIK细胞序贯治疗5例老年急性髓系白血病患者疗效评价
Evaluate the clinical effectiveness of autologous cytokine-inducedkiller cells sequential therapy after chemotherapy of elderly patients with acute myeloid leukemia
摘要
Abstract
Objective To preliminary observe and evaluate the clinical effectiveness of autologous cytokine-induced killer(CIK) cells sequential therapy after chemotherapy of elderly patients with acute myeloid leukemia(AML),then build a new maintenance therapeutic method with less side effects for AML.Methods Five elderly patients with AML were selected as the research objects, who achieved complete remission or partial remission have weak tolerance to continue chemotherapy.The five patients' general symptoms and adverse reaction, cellular immune function, peripheral blood micro resist disease(MRD) lever, living quality and survival of five patients were observed and analyzed after CIK cells infusion.Results The results showed that no adverse reaction appeared in the 35 cycles CIK cells infusion for 5 patients.After the infusion 5 patients' spirit, appetite, physical strength were improved.After the CIK infusion, the percentage of regulate T cells and effect T cells 2.70±1.59 was reduced compared with 5.35±5.50 before the CIK infusion (P<0.05).After the CIK infusion the level of MRD(0.16±0.30)% was significantly reduced compared with (0.86±0.84)% before the CIK infusion (P<0.05).After the CIK infusion the goal of KPS 88.8±6.03 was ameliorate than 75.45±10.35 before the CIK infusion (P<0.05).Five patients' overall survival (OS) was 29.8 months.Conclusion Autologous CIK cells sequential maintenance therapy is safe and effective for the elder patients with AML.关键词
细胞因子诱导的杀伤细胞/急性髓细胞白血病/老年/疗效Key words
cytokine-induced killer cells/acute myeloid leukemia/elderly/effect分类
医药卫生引用本文复制引用
张欢,王会平,陶千山,张家奎,翟志敏,李迎伟,沈元元..化疗后CIK细胞序贯治疗5例老年急性髓系白血病患者疗效评价[J].安徽医科大学学报,2017,52(3):412-416,5.基金项目
国家自然科学基金(编号:81401293) （编号:81401293）
安徽高校省级自然科学研究重大项目(编号:KJ2014ZD17) （编号:KJ2014ZD17）
