安徽中医药大学学报2017，Vol.36Issue(2)：76-79,4.DOI:10.3969/j.issn.2095-7246.2017.02.021
去甲斑蝥素固体自微乳制备及稳定性考察
Preparation and stability of norcantharidin solid self-microemulsion
摘要
Abstract
Objective To investigate the preparation and stability of norcantharidin solid self-microemulsion.Methods With encapsulation efficiency and yield as evaluation indices, the spherical crystallization technique was used for preparation, and an orthogonal design was used for the optimization of preparation process to realize the solidification of norcantharidin self-microemulsion in a single step.Norcantharidin solid self-microemulsion was evaluated in the aspects of particle size, potential, self-emulsifying rate, and stability.Results The best prescription of norcantharidin self-microemulsion had a mean encapsulation efficiency of 77.39%, a mean yield of 84.5%, a particle size of 22.76 nm, and a Zeta potential of-2.77 mV.There was no significant difference in self-emulsifying rate between different media, and self-emulsification was completed within 50 seconds.The stability test showed that there were no changes in particle size, potential, or encapsulation efficiency of norcantharidin self-microemulsion at a temperature of 60 ℃ and after exposure to strong light.Conclusion The self-made norcantharidin solid self-microemulsion is stable and reliable.关键词
去甲斑蝥素/固体自微乳/正交试验法/包封率/稳定性Key words
Norcantharidin/Solid self-microemulsion/Orthogonal test/Encapsulation efficiency/Stability分类
医药卫生引用本文复制引用
桂贇,胡容峰,王斌,周红,金栋..去甲斑蝥素固体自微乳制备及稳定性考察[J].安徽中医药大学学报,2017,36(2):76-79,4.基金项目
国家自然科学基金项目(81274100,81573615) （81274100,81573615）
