北京中医药大学学报2017，Vol.40Issue(2)：98-102,5.DOI:10.3969/j.issn.1006-2157.2017.02.002
泌乳素——女性肝郁证一个潜在的生物表征物
Prolactin: A potential molecular marker of TCM pattern of liver depression in women
摘要
Abstract
Pattern of liver depression, a very common TCM pattern in patients especially in female patients, whose pathophysiological connotation in modern society is still to be explored.This paper attempts to find out the modern molecular mechanism of pattern of liver depression in women, based on the pathogenesis and clinical characteristics of the pattern, on the pathophysiological changes of female reproductive diseases related to the pattern and on the latest research findings of prolactin, combined with retrieving the literature of clinical or animal experiment related to prolactin-pattern-female diseases.The abnormal expression of prolactin can be found in diseases related to pattern of liver depression in women and all female animal model with pattern of liver depression, furthermore, TCM formula guided by the principle of soothing the liver could inhibit the overexpression of prolactin.As the result, the author proposes that prolactin has exact correlation with pattern of liver depression in women, and prolactin may be the novel target molecule of the pattern.The author expects that the clues could help to reveal the molecular mechanism of pattern of liver depression in women.关键词
肝郁证/女性疾病/泌乳素/分子靶标Key words
pattern of liver depression/women-only diseases/prolactin/molecular target分类
医药卫生引用本文复制引用
张媛凤,谢鸣,钱梦..泌乳素——女性肝郁证一个潜在的生物表征物[J].北京中医药大学学报,2017,40(2):98-102,5.基金项目
国家自然科学基金资助项目(No.81173193) （No.81173193）
