北京中医药大学学报2017，Vol.40Issue(2)：107-111,5.DOI:10.3969/j.issn.1006-2157.2017.02.004
从EPO信号通路途径探讨"肝藏血,主疏泄"的分子机制
Discussion on the molecular mechanism of "liver storing blood with controlling dispersion" based on erythropoietin signaling pathway
摘要
Abstract
Based on the connotation analysis of TCM term of "liver storing blood with controlling dispersion" combined with achievement of recent research of western medicine, this article puts forward that "liver storing blood" is not derived from the function of "controlling dispersion", but is the material barrier.The function of "controlling dispersion" reflects in "liver storing blood" in regulation of qi, spleen and stomach, reproduction or emotion, conversely, the normal function of "liver storing blood" relies on the normal function of "controlling dispersion".So this article attempts the first time to discuss the molecular mechanism of "liver storing blood with controlling dispersion" based on erythropoietin (EPO) signaling pathway.The effect of EPO on production or regulation of blood and against depression is the reliable basis for TCM theory of "liver storing blood with controlling dispersion".This study should provide the new idea to explore the mechanism of depression, premenstrual syndrome and other emotional diseases.关键词
促红细胞生成素/肝藏血/肝主疏泄/抗抑郁Key words
erythropoietin/liver storing blood/controlling the dispersion/antidepressant分类
医药卫生引用本文复制引用
张浩,魏盛,李倩,乔明琦..从EPO信号通路途径探讨"肝藏血,主疏泄"的分子机制[J].北京中医药大学学报,2017,40(2):107-111,5.基金项目
国家自然科学基金面上资助项目(No.81573854) （No.81573854）
