北京中医药大学学报2017，Vol.40Issue(2)：148-154,7.DOI:10.3969/j.issn.1006-2157.2017.02.012
阿萨伊对虚热证大鼠环核苷酸、神经及免疫水平的影响
Effect of A(c)aí on cyclic nucleotides, neurotransmitters and immune level of rats with asthenia pyrosyndrome
摘要
Abstract
Objective To study the effect of frozen fruit pulp of A(c)aí (Euterpe Oleraceae Mart.) on cyclic nucleotides, neurotransmitters and immune level of rats with asthenia pyrosyndrome.Methods SD rats were randomly divided into blank group, model group, Huangbo (Cortex Phellodendri Chinensis) group, Gegen Qinlian Decoction (a Chinese herbal medicine compound) group, A(c)aí high-dose group and A(c)aí low-dose group.The rat model of asthenia pyrosyndrome was induced by intramuscular injection of dexamethasone sodium phosphate at dose of 0.35 mg/kg once daily for consecutive 21 days.The level of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) were detected by radioimmunoassay.The levels of dopamine (DA), dopamine beta-hydroxylase (D-β-H) and norepinephrine (NE) were detected by enzyme immunoassay.The levels of IgG, IgM, C3 and C4 were detected by using colorimeter.The results of the groups were compared to analyze the effect of Huangbo, Gegen Qinlian Decoction and A(c)aí on rats with asthenia pyrosyndrome.Results High dose A(c)aí could relieve the symptoms due to asthenia pyrosyndrome, and decreased the serum level of cAMP, cGMP, cAMP/cGMP, DA, D-β-H and NE (P<0.05), while increased the serum content of IgG, IgM and C3 (P<0.05,P<0.001 or P<0.05).Conclusion The effect of A(c)aí on cyclic nucleotides, neurotransmitters and immune level was similar with that of Huangbo or Gegen Qinlian Decotion, which proved the cold property of A(c)aí.关键词
阿萨伊/虚热证/中药药性/环核苷酸/神经递质/免疫物质/补体/大鼠Key words
A(c)aí/asthenia pyrosyndrome/property of Chinese herbal medicine/cyclic nucleotides/neurotransmitter/immunities/complement/rats分类
医药卫生引用本文复制引用
王子晨,王林元,朱映黎,唐潇然,王莎,瞿研,张建军..阿萨伊对虚热证大鼠环核苷酸、神经及免疫水平的影响[J].北京中医药大学学报,2017,40(2):148-154,7.基金项目
北京中医药大学中青年教师资助项目(No.2016-JYB-JSPY-013),北京中医药大学在读研究生资助项目(No.2015-JYB-XS002) （No.2016-JYB-JSPY-013）
