北京中医药大学学报2017，Vol.40Issue(2)：172-176,5.DOI:10.3969/j.issn.1006-2157.2017.02.016
从肝肾论治围绝经期失眠的临床疗效Meta分析
Clinical effect of traditional Chinese medicine therapy on perimenopausal insomnia from the standpoint of regulating liver and kidney:a Meta-analysis
摘要
Abstract
Objective To systematically evaluate the clinical efficacy and safety of the traditional Chinese medicine(TCM) therapy on perimenopausal insomnia from the standpoint of regulating liver and kidney.Methods Randomized controlled trials(RCT) on PubMed, EMbase, CNKI, Wanfang Database and VIP database from their inception to April 2016 were searched.Two researchers separately screened the literature, extracted data and evaluated the literature bias risk according to inclusive criteria and exclusive criteria.Then the Meta-analysis was operated using Rev Man 5.3 software.Results Altogether nine RCT with 678 patients were eligible.The result of Meta-analysis showed: the clinical effectiveness of experimental group (TCM therapy group) was superior to that of control group(RR=1.30,95%CI[1.11,1.52],P<0.05);the PSQI scores showed significant differences between the two groups (SMD=-1.16,95%CI[-2.12,-0.20],P<0.05),but SPIEGEL score did not.Although adverse reactions were appeared in five studies, the adverse reaction rate of the experimental group was lower significantly (RR=0.09,95%CI[0.04,0.22],P<0.05).Conclusion The experimental group achieved obvious clinical efficacy with less adverse effect.关键词
围绝经期/失眠/肝肾论治/Meta分析/系统综述Key words
perimenopause/insomnia/therapy on perimenopausal insomnia from the standpoint of regulating liver and kidney/Meta-analysis/systematic review分类
医药卫生引用本文复制引用
高毅东,张松涛,黄俊山,谢利坤,詹夏菲,邓晶晶..从肝肾论治围绝经期失眠的临床疗效Meta分析[J].北京中医药大学学报,2017,40(2):172-176,5.基金项目
国家自然科学基金资助项目(No.81173149),福建省卫计委资助项目(No.Wzln201301),福建省科技厅专项基金资助项目(No.2014R1035-1) （No.81173149）
