北京中医药大学学报2017，Vol.40Issue(3)：232-236,5.DOI:10.3969/j.issn.1006-2157.2017.02.010
冠心病阿司匹林抵抗临床危险因素及与中医证素相关性研究
Correlation between clinical risk factors of aspirin resistance and TCM patterns in coronary artery disease patients
摘要
Abstract
Objective To provide the evidence for prevention and treatment of aspirin resistance (AR) in coronary artery disease (CAD) patients by analyzing the prevalence, related risk factors of AR and the distribution rules of TCM patterns.Methods One hundred CAD patients were eligible, who were confirmed by angiography and took aspirin at dose of 100 mg per night for at least four weeks, at the average age of(68.95±8.91) years.All the patients were divided into three groups according to the platelet aggregation assay induced by arachidonic acid (AA,1 mmol/L).The platelet aggregation rate of ≥80%, ≥50% and <80%, or ≤50% was used to define AR, aspirin semiresistance (ASR) or aspirin sensitive (AS) respectively.Meanwhile, based on the experts advice and literature retrieving, TCM pattern factors of patients were identified as qi deficiency, sputum turbid, blood stasis, qi stagnation, yang deficiency, yin deficiency and cold stagnation.Then the risk factors and distribution of TCM patterns were compared among the three groups.Results There were 12 CAD patients of AR found, whose fasting blood glucose levels, serum creatinine, quantity of lesion and severe lesion in the coronary artery were higher than those of other two groups(P<0.05),but insulin levels two hours after meal was lower(P<0.05).There were no significant difference of TCM pattern distribution among the three groups (P>0.05).And the multivariate logistic regression analysis showed that serum fasting glucose level was a significant risk factor of aspirin resistance.Conclusion AR has a relative high prevelance.Fasting blood glucose level is closely associated with AR in CAD patients.In AR group, the deficiency pattern factors included qi deficiency and yin deficiency, while the main excessive pattern factors were blood stasis and sputum turbid.Aspirin sensibility has no effects on distribution of TCM pattern factors.关键词
冠心病/阿司匹林抵抗/中医证素分布/临床研究Key words
coronary artery disease/aspirin resistance/TCM pattern factors distribution/clinical study分类
医药卫生引用本文复制引用
刘晴晴,沈乐,俞鹏,陈建东,陈晓虎..冠心病阿司匹林抵抗临床危险因素及与中医证素相关性研究[J].北京中医药大学学报,2017,40(3):232-236,5.基金项目
国家自然科学基金资助项目(No.81273943) （No.81273943）
