川北医学院学报2017，Vol.32Issue(1)：20-22,3.DOI:10.3969/j.issn.1005-3697.2017.01.006
右美托咪定对肺癌根治术围手术期应激反应的影响研究
Study on the effect of dexmedetomidine on perioperative stress reaction in radical resection of lung cancer
摘要
Abstract
Objective:To discuss the effect of dexmedetomidine on perioperative stress reaction in radical resection of lung cancer.Methods:46 cases of lung cancer patients treated with thoracoscopic radical resection of lung cancer were selected as the research object,divided into observation group (n =23) and control group (n =23) randomly.the observation group was combined with application of dexmedetomidine in anesthesia,but the control group without dexmedetomidine,the changes of stress response and hemodynamics at before induction (t0),gas tube intubation (t1),surgery for 1H (t2),the end of operation (t3) and pull out tracheal intubation tube (t4) in the patients of two groups were compared,and the situation of sedation after tracheal extubation was compared.Results:The MAP and HR at t1 and t4 was significantly higher than that of t0 in both groups,the difference was statistically significant (P ＜ 0.05);the MAP,HR in observation group was significantly lower than these in the control group at t1,t4,the differences was statistically significant (P ＜ 0.05);The plasma norepinephrine,epinephrine and cortisol at t1,t2,t4 in both groups were significantly higher than these at t0,and the level of observation group was significantly lower than that of the control group,the differences were statistically significant (P ＜ 0.05);after 5min of tracheal extubation,the Ramsay sedation score in observation group was significantly higher than that in the control group (P ＜ 0.05).Conclusions:Dexmedetomidine assisted anesthesia can effectively alleviate perioperative stress reaction in radical resection of lung cancer,and is of benefit for maintain the stability of hemodynamics and postoperative recovery.关键词
右美托咪定/肺癌根治术/应激反应/血流动力学Key words
Dexmedetomidine/Radical resection of lung cancer/Stress reaction/Hemodynamics分类
医药卫生引用本文复制引用
张先政,杨帆,许斌兵,钟礼平..右美托咪定对肺癌根治术围手术期应激反应的影响研究[J].川北医学院学报,2017,32(1):20-22,3.基金项目
遂宁市科技局项目(2013S21) （2013S21）
