摘要
Abstract
Objective:To discuss the correlation between serum tumor necrosis factor-α (TNF-α) level and development quotient (DQ),GMFM-88 score and clinical significance in children with cerebral palsy.Methods:42 children with cerebral palsy were selected as the patients group,and the normal children were selected as the control group in the same period.The levels of TNF-α,IgA and IgG in serum of two groups were compared,and the correlation between DQ and GMFM-88 score was analyzed.The correlation between serum TNF-α and DQ,GMFM-88 score in the observation group was analyzed.Results:No significant differences between serum IgA and IgG levels in the two groups (P ＞ 0.05),but the serum levels of TNF-α (t =14.57,P ＜ 0.001) was significantly higher than the control group;DQ (t =10.18,P ＜ 0.001) and GMFM-88 (t =14.11,P ＜ 0.001) the observation group was significantly lower than that of control group;serum TNF-α and DQ (r =-0.478,P ＜0.001),GMFM-88 (r =-0.538,P ＜0.001) were negatively related,DQ and GMFM-88 (r =0.679,P ＜ 0.001) showed a significant positive correlation.Conclusions:The expression of serum TNFα in children with cerebral palsy alpha was significantly increased,and the DQ and GMFM-88 scores were negatively correlated,suggesting that TNF-α levels increase with brain damage,leading to influence the development of intelligence and gross motor,meanwhile the development of gross motor and intellectual were synchronous,early clinical related support should be strengthened.关键词
脑性瘫痪/适应性发育商/粗大运动功能评估量表/相关性分析/肿瘤坏死因子-αKey words
Cerebral palsy/Development quotient/GMFM-88/Correlation analysis/Tumor necrosis factor-α分类
医药卫生
