张丽 1田苗 2刘福兴 1张学艳 1马艳 1张红霞1
作者信息
- 1. 保定市第一中心医院神经内科,河北保定071000
- 2. 中国人民解放军白求恩国际和平医院急诊科,河北石家庄050082
- 折叠
摘要
Abstract
Objective:To study the effect of probucol on the level of on activated partial thromboplastin time (APTT),plasma fibrinogen (FIB) and the blood rheology at the stage of advanced cerebral infarction.Methods:82 patients undergoing the advanced cerebral infarction were randomly divided into experimental group (42 cases) and control group (40 cases).The experimental group were given probucol,0.25 g/times,2 times a day;While the control group were treated by routine method.After treatment,APTT,FIB and the blood rheology were compared before and after treatment.Results:(1) Systolic blood pressure,diastolic blood pressure,heart rate,fasting blood glucose,triglycerides and total cholesterol levels have no significant difference between the experimental group and the control group,but fasting glucose,triglycerides and total cholesterol levels are slightly higher.(2)APTT and FIB were improved in both groups after treatment,APTT in the experimental group increased (6.6 ± 0.24) s,which was higher than (3.7-± 0.17) s in the control group;FIB in the experimental group reduced (2.36-± 0.11) g/L,which was lower than (1.14-± 0.10) g/L in the control group with statistically significant difference (P ＜ 0.05);(3)The blood rheology were improved in two groups after treatment (including high shear rate,low shear rate,plasma viscosity).Experimental high shear rate decreased 1.6 ± 0.6,low shear rate decreased 4.7 ± 1.2,plasma viscosity decreased 0.5 ±-0.07,while the control group parameter value changes were 1.1 ± 0.9,3.6 ± 1.0,0.1 ± 0.09,respectively.The differences between two groups were statistically significant (P ＜ 0.05).Conclusions:Probucol could firmly improve the APTT,FIB and hemorheology of cerebral infarction at the advanced stage,which shows a worthy of clinical application.关键词
普罗布考/脑梗塞进展期/APTT/FIB/血液流变学Key words
Probucol/Cerebral infarction/APTT/FIB/Blood rheology分类
医药卫生
