长春中医药大学学报2017，Vol.33Issue(2)：188-191,4.DOI:10.13463/j.cnki.cczyy.2017.02.006
缺血后适应对大鼠大脑缺血再灌注脑损伤的S-100B蛋白、超敏感性C反应蛋白表达的影响
Effects of ischemic injury on the expression of S-100B protein and ultra sensitive C reactive protein in cerebral ischemia reperfusion injury in rats
摘要
Abstract
Objective To investigate adaptation ischemic cerebral ischemia- eperfusion injury (ischemia reperfusion injury, IRI) of S-100B protein, ultra- sensitivity C-reactive protein expression comparison sites in different time characteristics.Methods Using suture method cerebral artery occlusion and reperfusion animal model. Wistar rats were randomly divided into six groups: sham operation group (Sham group), IRI group, ischemic postconditioning (ischemia postconditioning, IP)Ⅰ-Ⅳ group. Content change of S-100B protein and super sensitive C reactive protein (h-CRP) in brain injury markers.Results Compared with the IRI group, the neurological deficits score, S-100B and C reactive protein (h-CRP) were significantly decreased in all groups, and the IP I-IV groups were increased in turn. The data were statistically significant.Conclusion After ischemia adaptation can improve the postoperative rats neural function defect score and down regulation of S-100B protein, hypersensitive C reaction protein expression, after focal cerebral ischemia reperfusion injury in rats has a protective effect.关键词
缺血再灌注损伤/S-100B蛋白/超敏感性C反应蛋白Key words
ischemia reperfusion injury/S-100B protein/super sensitive C reactive protein分类
医药卫生引用本文复制引用
林先刚,李兴亚,唐巍,陈业农..缺血后适应对大鼠大脑缺血再灌注脑损伤的S-100B蛋白、超敏感性C反应蛋白表达的影响[J].长春中医药大学学报,2017,33(2):188-191,4.基金项目
安徽省教育厅自然科学基金重点项目"基于RISK-PI3K信号通路研究脑络欣通干预局灶性脑缺血后适应的作用机制"(KJ2015A131) （KJ2015A131）
安徽中医学院自然科学基金项目"基于缺血后适应的益气活血中药干预再灌注大鼠脑损伤机制研究"(2013zr003) （2013zr003）
安徽中医药大学自然科学基金项目"姜黄素对香烟诱导COPD大鼠免疫失衡的影响"(2014qn002). （2014qn002）
