长春中医药大学学报2017，Vol.33Issue(2)：335-338,4.DOI:10.13463/j.cnki.cczyy.2017.02.058
中医药以脑啡肽酶为靶点预防阿尔茨海默病实验研究进展
Experimental research progress of neprilysin as a target for the prevention of alzheimer's disease
摘要
Abstract
Abnormal beta-amyloid (Aβ) aggregation and slow deposition are considered to be the core mechanism of alzheimer's disease. Restraining from the formation of senile plaques has become the important strategy of treatment of AD, and Aβ degradation enzyme in the process of Aβ clearance played an important role. Neprilysin as the main degradation enzyme of Aβ will be the key target for the treatment of AD. In the future, we should further study that up regulation of NEP activity and promotes Aβ clearance, and ultimately achieve the goal of treating AD.关键词
阿尔茨海默病/中医药疗法/脑啡肽酶Key words
alzheimer's disease/traditional Chinese medicine/neprilysin分类
医药卫生引用本文复制引用
周佳,李新新,周妍妍,王琪,柳广周,姚辛敏..中医药以脑啡肽酶为靶点预防阿尔茨海默病实验研究进展[J].长春中医药大学学报,2017,33(2):335-338,4.基金项目
国家自然科学青年基金"基于对β-淀粉样蛋白代谢酶调控作用的地黄饮子防治AD研究"(81573863) （81573863）
中国博士后科学基金面上资助项目(2015M571453) （2015M571453）
黑龙江省自然科学基金面上项目(H2016073). （H2016073）
