摘要
Abstract
Objective: To evaluate the diagnostic value of combining 3D artery spin labeling and intravoxel incoherent motion in grading of cerebral gliomas. Materials and Methods: A total of 32 patients with histopathology proved gliomas (13 low grade, 19 high grade) were included in this study. 3D ASL and multi-b IVIM images were retrospectively analyzed. The ASL and IVIM data were processed on workstation to get the CBF and D, D*, f values. The results were compared among high grade and low grade groups and P<0. 05 was regarded as statistically significant. Results: CBF were significantly higher in high grade gliomas than lower grade gliomas [(75.6±12.3) ml/(100g?min), (55.8±8.9) ml/(100g?min), respectively; P<0.001]. In bi-exponential IVIM model, the high grade gliomas of D* value also showed significantly higher than lower grade gliomas group [(40.3±23.5)×10-3 mm2/s, (19.2±7.5)×10-3 mm2/s, respectively;P<0.01)], but there had no difference of D [(0.73±0.26)×10-3 mm2/s, (0.59±0.15)× 10-3 mm2/s, respectively; P>0.05)] and f (11.1±6.9, 7.2±4.1, respectively; P>0.05). The area under AUC of combination of CBF and D* for glioma grading was 0.935 and corresponding diagnostic sensitivity and specificity were 91.5% and 89.6%. Conclusion:The combination of 3D ASL and IVIM parameters can be used to differentiate high grade glioma and low grade glioma. Combination of CBF and D* value obtain better diagnostic performance than other parameters.关键词
神经胶质瘤/动脉自旋标记:体素内不相干运动/磁共振成像/肿瘤分级Key words
Glioma/Artery spin labeling/Intravoxel incoherent motion/Magnetic resonance imaging/Neoplasm grading分类
医药卫生
