磁共振成像2017，Vol.8Issue(4)：248-253,6.DOI:10.12015/issn.1674-8034.2017.04.003
体素内不相干运动扩散加权成像对肝癌经导管肝动脉化疗栓塞治疗短期疗效预测及评估价值
The predictive value of IVIM-DWI on short-term therapeutic effect and prognosis of TACE on hepatocellular carcinoma
摘要
Abstract
Objective: To investigate the postoperative early response and short-term prognosis value of intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) quantitative parameters for the patients with hepatocellular carcinoma (HCC) treated by transcatheter arterial chemoembolization (TACE). Materials and Methods:Ninety patients with biopsy-proven or clinical diagnostic HCC underwent IVIM-DWI on a 3.0 T MR scanner before TACE, and 90 HCC patients took the same MR scan one month after TACE. The quantitative parameters were measured on the maximal tumor region, including D, D* and f value before and after TACE. The patients were divided into progress group and stable group based on mRECIST as criterion. All data were statistically analyzed. Results: There were significant differences between progress group and the stable group in D and D* values of the tumor before TACE (P<0.05, respectively). One month after TACE, the ΔD and ΔD* values of the tumor had significant differences between the two groups (P<0.05, respectively). The D and D* values of tumors had significant differences before and after TACE (P<0.05, respectively). Conclusion: The D, D* values of the IVIM-DWI could predict the efficacy before TACE in HCC patients. Furthermore, the IVIM-DWI as a noninvasive method might evaluate the early response after TACE in HCC patients.关键词
肝肿瘤/磁共振成像/扩散加权成像/体素内不相干运动/肝动脉/栓塞,治疗性Key words
Liver neoplasms/Magnetic resonance imaging/Diffusion-weighted imaging/Intravoxel incoherent motion/Hepatic artery/Embolization/therapeutic分类
医药卫生引用本文复制引用
马霄虹,王爽,赵心明,王倩,朱永健,欧阳汉,周纯武..体素内不相干运动扩散加权成像对肝癌经导管肝动脉化疗栓塞治疗短期疗效预测及评估价值[J].磁共振成像,2017,8(4):248-253,6.基金项目
公益性行业科研专项基金资助(编号:201402019) （编号:201402019）
中国癌症基金会北京马拉松专项基金资助(编号:LC2016B15) ACKNOWLEDGMENTS This work was part of Public Welfare Scientific Research Project of Chinese Academy of Medical Sciences (No. 201402019) （编号:LC2016B15）
Beijing Hope Run Special Fund of Cancer Foundation of China (No. LC2016B15). （No. LC2016B15）
