磁共振成像2017，Vol.8Issue(4)：289-295,7.DOI:10.12015/issn.1674-8034.2017.04.010
原发性全面强直阵挛癫痫大脑-小脑功能连通性的静息态功能磁共振成像研究
Cerebro-cerebellar functional connectivity in patients with generalized tonic-clonic seizure: a resting state functional MRI study
摘要
Abstract
Objective: To explore the altered features of cerebro-cerebellar functional connectivity in resting-state during the interictal time of generalized tonic-clonic seizure (GTCS). Materials and Methods: Nineteen patients with GTCS and 22 age-, sex-, education- and handedness-matched healthy controls (HCs) were recruited. All the individuals' resting-state fMRI data were acquired in a Siemens 3.0 T MR. Firstly, amplitude of low-frequency fluctuations (ALFF) was applied to investigate the changes of whole brain spontaneous functional activity caused by GTCS. Then resting-state functional connectivity (rsFC) was calculated between seeds regions based on ALFF group differences in cerebrum (cerebellum) and all voxels in cerebellum (cerebrum). Finally, the correlation analysis was performed between ALFF/rsFC and NHS3 scores in brain regions with significant group differences. Results: Compared with the HCs, the patients with GTCS exhibit significantly increased ALFF in the right hippocampus, right cerebellar_crus2 and left cerebellar_4_5, but significantly decreased in the right precuneus and left middle frontal gyrus. Seed-based rsFC analysis showed that rsFC in patients with GTCS was significantly increased in the left cerebellar_8, right cerebellar_4_5, and right cerebellar_4_5, but significantly decreased in the left inferior frontal gyrus and right middle temporal gyrus. Furthermore, correlation analysis exhibit the positively correlated between NHS3 scores and rsFC of the left cerebellar_8 (r=0.48, P=0.036) in patients with GTCS, but negatively correlated between NHS3 scores and rsFC of the right middle temporal gyrus (r=-0.34, P=0.042) in patients with GTCS. Conclusion:Cerebro-cerebellar resting-state functional connectivity was abnormal during the interictal time of GTCS, which may be associated with the pathophysiological mechanism and clinical manifestations in patients with GTCS.关键词
癫痫,强直阵挛性/低频振幅/小脑/功能连通性/磁共振成像,功能性Key words
Epilepsy/tonic-clonic/Amplitude of low-frequency fluctuations/Cerebellum/Functional connectivity/Magnetic resonance imaging/functional分类
医药卫生引用本文复制引用
穆颖,张喆,刘光耀,刘宏,张静,凡振玉..原发性全面强直阵挛癫痫大脑-小脑功能连通性的静息态功能磁共振成像研究[J].磁共振成像,2017,8(4):289-295,7.基金项目
甘肃省青年科技基金计划项目(编号:1506RJYA218) （编号:1506RJYA218）
兰州工业学院青年科技创新项目(编号:2014K-007) ACKNOWLEDGMENTS This work was part of Gansu Province Natural Science Foundation (No.1506RJYA218) （编号:2014K-007）
The Scientific Innovation Foundation of Lanzhou Institute of Technology (No.2014K-007). （No.2014K-007）
